Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADAMTS4 | O75173 | 4/20 | 0.75 |
| ▸ | MMP2 | P08253 | 11/20 | 0.68 |
| ▸ | MMP9 | P14780 | 9/20 | 0.68 |
| ▸ | MMP3 | P08254 | 5/20 | 0.62 |
| ▸ | MMP13 | P45452 | 5/20 | 0.62 |
| ▸ | MMP1 | P03956 | 5/20 | 0.62 |
| ▸ | MMP7 | P09237 | 4/20 | 0.62 |
| ▸ | MMP14 | P50281 | 1/20 | 0.61 |
| ▸ | ADAM17 | P78536 | 1/20 | 0.61 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.57 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.57 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.57 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14216845 | 0.87 | MMP2 (0.62) | ADAMTS4MMP2MMP9MMP3MMP13 | |
| SCHEMBL4651862 | 0.86 | ADAMTS4 (1.00) | ADAMTS4MMP2MMP9MMP3MMP13 | |
| SCHEMBL1751961 | 0.86 | ADAMTS4 (1.00) | ADAMTS4MMP2MMP9MMP3MMP13 | |
| SCHEMBL32691800 | 0.85 | MMP2 (0.80) | ADAMTS4MMP2MMP9MMP3MMP13 | |
| SCHEMBL1800250 | 0.84 | MMP13 (0.76) | ADAMTS4MMP2MMP9MMP3MMP13 | |
| SCHEMBL1800247 | 0.84 | MMP13 (0.76) | ADAMTS4MMP2MMP9MMP3MMP13 | |
| SCHEMBL31086764 | 0.84 | MMP2 (0.71) | ADAMTS4MMP2MMP9MMP3MMP13 | |
| SCHEMBL405125 | 0.84 | MMP9 (0.66) | ADAMTS4MMP2MMP9MMP3MMP13 | |
| SCHEMBL4915104 | 0.84 | MMP9 (0.66) | ADAMTS4MMP2MMP9MMP3MMP13 | |
| SCHEMBL7414131 | 0.83 | MMP2 (0.68) | ADAMTS4MMP2MMP9MMP3MMP13 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1644031-A1 | INHIBITORS OF THE LEUKOCYTE PROMMP-9/BETA(2) INTEGRIN COMPLEX | CTT Cancer Targeting Technologies OY (FI) | 2006-04-12 | — | — | EP | disclosed |
| WO-2004110477-A1 | INHIBITORS OF THE LEUKOCYTE PROMMP-9/BETA(2) INTEGRIN COMPLEX | CTT CANCER TARGETING TECHNOLOGIES OY (FI) | 2004-12-23 | — | — | WO | disclosed |