Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 2/20 | 0.50 |
| ▸ | AKR1B10 | O60218 | 3/20 | 0.44 |
| ▸ | AKR1B1 | P15121 | 3/20 | 0.44 |
| ▸ | CA12 | O43570 | 1/20 | 0.44 |
| ▸ | CA4 | P22748 | 1/20 | 0.44 |
| ▸ | CA6 | P23280 | 1/20 | 0.44 |
| ▸ | CA5A | P35218 | 1/20 | 0.44 |
| ▸ | CA7 | P43166 | 1/20 | 0.44 |
| ▸ | CA9 | Q16790 | 1/20 | 0.44 |
| ▸ | CA14 | Q9ULX7 | 1/20 | 0.44 |
| ▸ | CA5B | Q9Y2D0 | 1/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.43 |
| ▸ | L3MBTL1 | Q9Y468 | 3/20 | 0.43 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.43 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.43 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.43 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.43 |
| ▸ | TSHR | P16473 | 1/20 | 0.43 |
| ▸ | CNR2 | P34972 | 1/20 | 0.41 |
| ▸ | HCAR2 | Q8TDS4 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3073240 | 0.85 | POLB (0.43) | LMNAALDH1A1L3MBTL1TDP1ADORA3 | |
| SCHEMBL3072451 | 0.83 | CYP1A2 (0.46) | LMNAL3MBTL1TDP1CNR2KMT2A | |
| SCHEMBL3072447 | 0.83 | CYP1A2 (0.46) | LMNAL3MBTL1TDP1CNR2KMT2A | |
| SCHEMBL5693245 | 0.83 | CYP1A2 (0.46) | LMNAL3MBTL1TDP1CNR2KMT2A | |
| SCHEMBL3053051 | 0.83 | CYP1A2 (0.46) | LMNAL3MBTL1TDP1CNR2KMT2A | |
| SCHEMBL3053052 | 0.83 | CYP1A2 (0.46) | LMNAL3MBTL1TDP1CNR2KMT2A | |
| SCHEMBL3063635 | 0.80 | LMNA (0.54) | LMNAAKR1B10AKR1B1CA12CA4 | |
| SCHEMBL9345204 | 0.78 | LMNA (0.52) | LMNAAKR1B10AKR1B1CA12CA4 | |
| SCHEMBL11543059 | 0.75 | LMNA (0.55) | LMNAAKR1B10AKR1B1CA12CA4 | |
| SCHEMBL22487746 | 0.75 | ALDH1A1 (0.50) | LMNAALDH1A1L3MBTL1MAPK1TDP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1658260-A1 | BUTENOIC ACID DERIVATIVES, PROCESSES FOR THE PREPARATION THEREOF, PHARMACEUTICAL COMPOSITIONS COMPRISING THEM, AND USE FOR THE TREATMENT OF DYSLIPIDAEMIA, ATHEROSCLEROSIS AND DIABETES | Merk Patent Gmbh (DE) | 2006-05-24 | — | — | EP | claimed |
| WO-2005014521-A1 | BUTENOIC ACID DERIVATIVES, PROCESSES FOR THE PREPARATION THEREOF, PHARMACEUTICAL COMPOSITIONS COMPRISING THEM, AND USE FOR THE TREATMENT OF DYSLIPIDAEMIA, ATHEROSCLEROSIS AND DIABETES | MERK PATENT GMBH (DE) | 2005-02-17 | — | — | WO | claimed |