Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FABP4 | P15090 | 6/20 | 0.54 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.48 |
| ▸ | FABP3 | P05413 | 2/20 | 0.47 |
| ▸ | FABP5 | Q01469 | 1/20 | 0.47 |
| ▸ | PIK3CD | O00329 | 2/20 | 0.44 |
| ▸ | PIK3CA | P42336 | 2/20 | 0.44 |
| ▸ | PIK3CB | P42338 | 2/20 | 0.44 |
| ▸ | PIK3CG | P48736 | 2/20 | 0.44 |
| ▸ | PSEN1 | P49768 | 2/20 | 0.37 |
| ▸ | PSEN2 | P49810 | 2/20 | 0.37 |
| ▸ | APH1B | Q8WW43 | 2/20 | 0.37 |
| ▸ | NCSTN | Q92542 | 2/20 | 0.37 |
| ▸ | APH1A | Q96BI3 | 2/20 | 0.37 |
| ▸ | PSENEN | Q9NZ42 | 2/20 | 0.37 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.37 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.37 |
| ▸ | GAA | P10253 | 1/20 | 0.36 |
| ▸ | GABRA1 | P14867 | 1/20 | 0.35 |
| ▸ | GABRB2 | P47870 | 1/20 | 0.35 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9498378 | 0.79 | FABP4 (0.57) | FABP4ALDH1A1FABP3FABP5PIK3CD | |
| SCHEMBL5686154 | 0.76 | FABP4 (0.57) | FABP4ALDH1A1FABP3FABP5PIK3CD | |
| SCHEMBL5694221 | 0.71 | RAPGEF4 (0.45) | ALDH1A1PIK3CDPIK3CAPIK3CBPIK3CG | |
| SCHEMBL29742381 | 0.71 | GAA (0.35) | ALDH1A1NOTUMGAA | |
| SCHEMBL9108321 | 0.70 | FABP4 (1.00) | FABP4ALDH1A1FABP3FABP5PSEN1 | |
| SCHEMBL840945 | 0.70 | FABP4 (1.00) | FABP4ALDH1A1FABP3FABP5PSEN1 | |
| SCHEMBL1123484 | 0.70 | FABP4 (0.47) | FABP4ALDH1A1FABP3FABP5PIK3CD | |
| SCHEMBL8989764 | 0.68 | FABP4 (0.69) | FABP4ALDH1A1FABP3FABP5PIK3CD | |
| SCHEMBL4246719 | 0.68 | FABP4 (0.62) | FABP4ALDH1A1FABP3FABP5PIK3CD | |
| SCHEMBL2946584 | 0.68 | FABP4 (0.62) | FABP4ALDH1A1FABP3FABP5GAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 60 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4373071-A | RESIN SUPPORTS; GENETIC ENGINEERING | CITY OF HOPE RESEARCH INSTITUTE (US) | 1983-02-08 | — | — | US | claimed |
| US-20230123981-A1 | 4'-O-METHYLENE PHOSPHONATE NUCLEIC ACIDS AND ANALOGUES THEREOF | NOVO NORDISK A/S (DK) | 2023-04-20 | — | — | US | disclosed |
| EP-4090665-A1 | 4'-O-METHYLENE PHOSPHONATE NUCLEIC ACIDS AND ANALOGUES THEREOF | Dicerna Pharmaceuticals, Inc. (US) | 2022-11-23 | — | — | EP | disclosed |
| CN-115298192-A | 4' -O-methylene phosphonate nucleic acids and analogs thereof | 迪克纳制药公司 | 2022-11-04 | — | — | CN | disclosed |
| WO-2021146488-A1 | 4'-O-METHYLENE PHOSPHONATE NUCLEIC ACIDS AND ANALOGUES THEREOF | DICERNA PHARMACEUTICALS, INC. (US) | 2021-07-22 | — | — | WO | disclosed |
| US-20060167241-A1 | Method for synthesizing cyclic bisdinucleoside | MITSUI CHEMICALS, INC. (JP) | 2006-07-27 | — | — | US | disclosed |
| EP-1645561-A1 | METHOD OF SYNTHESIZING CYCLIC BISDINUCLEOSIDE | Mitsui Chemicals, Inc. (JP) | 2006-04-12 | — | — | EP | disclosed |
| US-5750380-A | DNA polymerase mediated synthesis of double stranded nucleic acids | CITY OF HOPE RESEARCH INSTITUTE (US) | 1998-05-12 | — | — | US | disclosed |
| US-5583013-A | EXPRESSION IN A MICROORGANISM TRANSFORMED WITH A REPLICABLE CLONING VEHICLE; ENCODING DNA IS UNDER THE OPERATIVE CONTROL OF AN EXPRESSION CONTROL REGION | GENENTECH, INC. (US) | 1996-12-10 | — | — | US | disclosed |
| US-5548076-A | CONDENSING A BLOCKED NUCLEOSIDE BOUND TO A CARRIER | GENENTECH, INC. (US) | 1996-08-20 | — | — | US | disclosed |
| US-4366246-A | Method for microbial polypeptide expression | GENENTECH, INC. (US) | 1982-12-28 | — | — | US | disclosed |
| US-4356270-A | Recombinant DNA cloning vehicle | GENENTECH, INC. (US) | 1982-10-26 | — | — | US | disclosed |
| EP-0049619-A2 | Method for stabilizing and selecting host cells containing recombinant DNA | ELI LILLY AND COMPANY (US) | 1982-04-14 | — | — | EP | disclosed |
| US-4310662-A | Nucleosidic phosphorylating agent and methods | GENENTECH, INC. (US) | 1982-01-12 | — | — | US | disclosed |
| EP-0035454-A2 | Desacetylthymosin alpha 1, its process of preparation and its use | GENENTECH, INC. (US) | 1981-09-09 | — | — | EP | disclosed |
| EP-0002322-A2 | Improved Triester process for the synthesis of oligonucleotides | GENENTECH, INC. (US) | 1979-06-13 | — | — | EP | disclosed |
| EP-0001931-A2 | Synthetic DNA, process for preparing it and recombinant microbial cloning vehicle containing such DNA | GENENTECH, INC. (US) | 1979-05-16 | — | — | EP | disclosed |
| EP-0001930-A2 | Method for polypeptide production involving expression of a heterologous gene, recombinant microbial cloning vehicle containing said gene and bacterial culture transformed by said cloning vehicle | GENENTECH, INC. (US) | 1979-05-16 | — | — | EP | disclosed |
| EP-0001929-A2 | Plasmid for transforming bacterial host to render it capable of polypeptide expression | GENENTECH, INC. (US) | 1979-05-16 | — | — | EP | disclosed |
| US-4059592-A | COUPLING AGENTS | CANADIAN PATENTS AND DEVELOPMENT LIMITED (CA) | 1977-11-22 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20060167241-A1 | Method for synthesizing cyclic bisdinucleoside | NSUN2, POLR2H, POLB | FABP4 4691/4885ALDH1A1 2897/4885FABP3 4465/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.