Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MMP12 | P39900 | 11/20 | 1.00 |
| ▸ | MMP13 | P45452 | 7/20 | 0.60 |
| ▸ | MMP2 | P08253 | 1/20 | 0.60 |
| ▸ | MMP9 | P14780 | 1/20 | 0.60 |
| ▸ | MMP14 | P50281 | 1/20 | 0.60 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.49 |
| ▸ | MGLL | Q99685 | 1/20 | 0.45 |
| ▸ | MME | P08473 | 1/20 | 0.45 |
| ▸ | ABCC4 | O15439 | 1/20 | 0.44 |
| ▸ | LMNA | P02545 | 1/20 | 0.44 |
| ▸ | GAA | P10253 | 1/20 | 0.44 |
| ▸ | TSHR | P16473 | 1/20 | 0.44 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.44 |
| ▸ | HTT | P42858 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5613478 | 0.84 | MMP12 (0.73) | MMP12MMP13MMP2MMP9MMP14 | |
| SCHEMBL14088148 | 0.82 | MMP12 (0.70) | MMP12MMP13MMP2MMP9MMP14 | |
| SCHEMBL11394897 | 0.82 | MMP12 (0.69) | MMP12TSHRHTT | |
| SCHEMBL7279889 | 0.81 | MMP12 (0.68) | MMP12TSHRHTT | |
| SCHEMBL14088146 | 0.80 | MMP12 (0.67) | MMP12MMP13MMP2MMP9MMP14 | |
| SCHEMBL14088134 | 0.79 | MMP12 (0.65) | MMP12MMP13MMP2MMP9MMP14 | |
| SCHEMBL6505903 | 0.78 | MMP12 (0.64) | MMP12MMP13MMP2MMP9MMP14 | |
| SCHEMBL11875805 | 0.77 | MMP12 (0.69) | MMP12MMP13MMP2MMP9MMP14 | |
| SCHEMBL4725100 | 0.76 | MMP12 (0.61) | MMP12TSHRHTT | |
| SCHEMBL7758600 | 0.75 | MMP12 (0.60) | MMP12MMP13MMP2MMP9MMP14 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1654213-A1 | MATRIX METALLOPROTEINASE INHIBITORS | GLAXO GROUP LIMITED (GB) | 2006-05-10 | — | — | EP | disclosed |
| WO-2004110974-A1 | MATRIX METALLOPROTEINASE INHIBITORS | GLAXO GROUP LIMITED (GB) | 2004-12-23 | — | — | WO | disclosed |