Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MMP12 | P39900 | 3/20 | 0.60 |
| ▸ | MMP2 | P08253 | 13/20 | 0.57 |
| ▸ | MMP9 | P14780 | 1/20 | 0.57 |
| ▸ | MMP13 | P45452 | 1/20 | 0.57 |
| ▸ | MMP14 | P50281 | 1/20 | 0.57 |
| ▸ | MMP3 | P08254 | 4/20 | 0.53 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7763242 | 0.86 | MMP2 (0.52) | MMP12MMP2MMP9MMP13MMP14 | |
| SCHEMBL7763247 | 0.86 | MMP2 (0.52) | MMP12MMP2MMP9MMP13MMP14 | |
| SCHEMBL7761567 | 0.80 | MMP2 (0.60) | MMP2MMP3 | |
| SCHEMBL7761563 | 0.80 | MMP2 (0.60) | MMP2MMP3 | |
| SCHEMBL5744885 | 0.80 | HDAC2 (0.49) | MMP12MMP2MMP9MMP13MMP14 | |
| SCHEMBL7765346 | 0.79 | MMP2 (0.47) | MMP12MMP2MMP9MMP13MMP14 | |
| SCHEMBL16980966 | 0.78 | MMP12 (0.69) | MMP12MMP2MMP9MMP13MMP14 | |
| SCHEMBL7319632 | 0.78 | GRIK1 (0.64) | MMP2MMP3 | |
| SCHEMBL7762255 | 0.78 | MMP2 (0.49) | MMP12MMP2MMP9MMP13MMP14 | |
| SCHEMBL7765152 | 0.78 | MMP2 (0.55) | MMP12MMP2MMP3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1098662-A2 | COADMINISTRATION OF ACAT AND MMP INHIBITORS FOR THE TREATMENT OF ATHEROSCLEROTIC LESIONS | WARNER-LAMBERT COMPANY (US) | 2001-05-16 | — | — | EP | claimed |
| WO-2000004892-A2 | COADMINISTRATION OF ACAT AND MMP INHIBITORS FOR THE TREATMENT OF ATHEROSCLEROTIC LESIONS | WARNER-LAMBERT COMPANY (US) | 2000-02-03 | — | — | WO | claimed |
| EP-1098662-A2 | COADMINISTRATION OF ACAT AND MMP INHIBITORS FOR THE TREATMENT OF ATHEROSCLEROTIC LESIONS | WARNER-LAMBERT COMPANY (US) | 2001-05-16 | — | — | EP | disclosed |
| WO-2000004892-A2 | COADMINISTRATION OF ACAT AND MMP INHIBITORS FOR THE TREATMENT OF ATHEROSCLEROTIC LESIONS | WARNER-LAMBERT COMPANY (US) | 2000-02-03 | — | — | WO | disclosed |