Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK1 | P28482 | 1/20 | 0.66 |
| ▸ | GAA | P10253 | 1/20 | 0.65 |
| ▸ | HTT | P42858 | 1/20 | 0.65 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.58 |
| ▸ | TP53 | P04637 | 1/20 | 0.55 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.55 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.54 |
| ▸ | TSHR | P16473 | 2/20 | 0.53 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.53 |
| ▸ | THRB | P10828 | 1/20 | 0.53 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.53 |
| ▸ | PTGS2 | P35354 | 5/20 | 0.53 |
| ▸ | PTGS1 | P23219 | 4/20 | 0.53 |
| ▸ | AKR1C3 | P42330 | 4/20 | 0.53 |
| ▸ | AKR1C2 | P52895 | 3/20 | 0.53 |
| ▸ | LMNA | P02545 | 2/20 | 0.53 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.53 |
| ▸ | CXCR1 | P25024 | 2/20 | 0.53 |
| ▸ | CXCR2 | P25025 | 2/20 | 0.53 |
| ▸ | RARB | P10826 | 2/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7403967 | 0.85 | GPR88 (0.59) | PTGS2PTGS1AKR1C3AKR1C2LMNA | |
| SCHEMBL8403335 | 0.85 | GPR88 (0.59) | PTGS2PTGS1AKR1C3AKR1C2LMNA | |
| SCHEMBL14599721 | 0.85 | GPR88 (0.59) | MAPK1TP53SMN1; SMN2TSHRPTGS2 | |
| SCHEMBL1346573 | 0.83 | POLB (0.51) | GAAHTTTDP1TSHRPTGS2 | |
| SCHEMBL8463046 | 0.83 | AKR1C3 (0.51) | MAPK1GAAHTTTDP1TSHR | |
| SCHEMBL11595380 | 0.83 | POLB (0.51) | GAAHTTTDP1TSHRPTGS2 | |
| SCHEMBL1749031 | 0.83 | MAPT (0.60) | TSHRPTGS2PTGS1AKR1C3AKR1C2 | |
| SCHEMBL9861070 | 0.82 | LMNA (0.62) | TP53TDP1TSHRAKR1C3AKR1C2 | |
| SCHEMBL11597542 | 0.82 | PPARG (0.51) | GAAHTTTDP1TSHRALDH1A1 | |
| SCHEMBL5881684 | 0.81 | AKR1C3 (0.73) | TSHRALDH1A1PTGS2PTGS1AKR1C3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1654218-A2 | MATRIX METALLOPROTEINASE INHIBITORS | GLAXO GROUP LIMITED (GB) | 2006-05-10 | — | — | EP | disclosed |
| WO-2005016868-A2 | MATRIX METALLOPROTEINASE INHIBITORS | GLAXO GROUP LIMITED (GB) | 2005-02-24 | — | — | WO | disclosed |