Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 1/20 | 0.51 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.51 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.51 |
| ▸ | AKR1C3 | P42330 | 5/20 | 0.51 |
| ▸ | AKR1C2 | P52895 | 4/20 | 0.51 |
| ▸ | GPR88 | Q9GZN0 | 6/20 | 0.51 |
| ▸ | PTGS2 | P35354 | 9/20 | 0.50 |
| ▸ | PTGS1 | P23219 | 6/20 | 0.49 |
| ▸ | LMNA | P02545 | 2/20 | 0.49 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.49 |
| ▸ | CXCR1 | P25024 | 2/20 | 0.49 |
| ▸ | CXCR2 | P25025 | 2/20 | 0.49 |
| ▸ | SLC22A6 | Q4U2R8 | 2/20 | 0.49 |
| ▸ | TSHR | P16473 | 2/20 | 0.49 |
| ▸ | ALB | P02768 | 1/20 | 0.49 |
| ▸ | ESR1 | P03372 | 1/20 | 0.49 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.49 |
| ▸ | RARB | P10826 | 1/20 | 0.49 |
| ▸ | ADRB3 | P13945 | 1/20 | 0.49 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1532485 | 0.94 | POLB (0.53) | POLBTDP1L3MBTL1AKR1C3AKR1C2 | |
| SCHEMBL9629526 | 0.88 | MEN1 (0.50) | POLBTDP1L3MBTL1AKR1C3AKR1C2 | |
| SCHEMBL14599721 | 0.88 | GPR88 (0.59) | POLBAKR1C3AKR1C2GPR88PTGS2 | |
| SCHEMBL11595380 | 0.87 | POLB (0.51) | POLBTDP1L3MBTL1AKR1C3AKR1C2 | |
| SCHEMBL9861070 | 0.85 | LMNA (0.62) | POLBTDP1L3MBTL1AKR1C3AKR1C2 | |
| SCHEMBL7403967 | 0.85 | GPR88 (0.59) | L3MBTL1AKR1C3AKR1C2GPR88PTGS2 | |
| SCHEMBL8403335 | 0.85 | GPR88 (0.59) | L3MBTL1AKR1C3AKR1C2GPR88PTGS2 | |
| SCHEMBL14599980 | 0.84 | LMNA (0.64) | POLBGPR88LMNATSHRRARB | |
| SCHEMBL11596837 | 0.84 | PPARA (0.50) | POLBTDP1L3MBTL1AKR1C3AKR1C2 | |
| SCHEMBL6414796 | 0.84 | LMNA (0.64) | POLBGPR88LMNATSHRRARB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8063223-B2 | Benzylpiperizine compound | DAINIPPON SUMITOMO PHARMA CO., LTD. (JP) | 2011-11-22 | — | — | US | disclosed |
| US-20110118312-A1 | BENZYLPIPERIZINE COMPOUND | DAINIPPON SUMITOMO PHARMA CO., LTD. (JP) | 2011-05-19 | — | — | US | disclosed |
| US-5179124-A | Nonsteroid antiinflammatory agents | UNIVERSITY OF IOWA RESEARCH FOUNDATION (US) | 1993-01-12 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110118312-A1 | BENZYLPIPERIZINE COMPOUND | OPRM1, GRM1, CHRM1 | POLB 1672/4885TDP1 2030/4885L3MBTL1 932/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.