Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CNR2 | P34972 | 1/20 | 0.39 |
| ▸ | MEN1 | O00255 | 2/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.36 |
| ▸ | TSHR | P16473 | 1/20 | 0.36 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.36 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.36 |
| ▸ | CXCR2 | P25025 | 1/20 | 0.35 |
| ▸ | AKR1C1 | Q04828 | 1/20 | 0.35 |
| ▸ | ANPEP | P15144 | 2/20 | 0.35 |
| ▸ | ERAP1 | Q9NZ08 | 2/20 | 0.35 |
| ▸ | ERAP2 | Q6P179 | 1/20 | 0.35 |
| ▸ | HTT | P42858 | 1/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.35 |
| ▸ | HPGD | P15428 | 1/20 | 0.35 |
| ▸ | ACE | P12821 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1818488 | 0.70 | AKR1C1 (0.37) | TSHRAKR1C1 | |
| SCHEMBL23884534 | 0.70 | AKR1C1 (0.37) | TSHRAKR1C1 | |
| SCHEMBL7455945 | 0.69 | SLC6A2 (0.52) | AKR1C1HTT | |
| SCHEMBL8083651 | 0.69 | SLC6A2 (0.52) | AKR1C1HTT | |
| SCHEMBL1819009 | 0.68 | ARG1 (0.50) | MEN1KMT2ACYP3A4CYP2C19SMN1; SMN2 | |
| SCHEMBL11243304 | 0.68 | LMNA (0.37) | TSHRAKR1C1SMN1; SMN2HPGD | |
| SCHEMBL29274948 | 0.68 | ARG1 (0.50) | MEN1KMT2ACYP3A4CYP2C19SMN1; SMN2 | |
| SCHEMBL10992272 | 0.68 | LMNA (0.37) | MEN1KMT2ATSHRSMN1; SMN2 | |
| SCHEMBL11239413 | 0.68 | LMNA (0.37) | MEN1KMT2ATSHRSMN1; SMN2 | |
| SCHEMBL9763836 | 0.67 | ALDH1A1 (0.40) | MEN1KMT2ACYP2C19AKR1C1HTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1666053-A1 | Methods and compositions for stimulating neurite growth using compounds with affinity for fkbp12 in combination with neurotrophic factors | Vertex Pharmceuticals Incorporated (US) | 2006-06-07 | — | — | EP | claimed |
| EP-0941113-A1 | METHODS AND COMPOSITIONS FOR STIMULATING NEURITE GROWTH USING COMPOUNDS WITH AFFINITY FOR FKBP12 IN COMBINATION WITH NEUROTROPHIC FACTORS | Vertex Pharmaceuticals Incorporated (US) | 1999-09-15 | — | — | EP | claimed |
| WO-1998020893-A1 | METHODS AND COMPOSITIONS FOR STIMULATING NEURITE GROWTH USING COMPOUNDS WITH AFFINITY FOR FKBP12 IN COMBINATION WITH NEUROTROPHIC FACTORS | VERTEX PHARMACEUTICALS INCORPORATED (US) | 1998-05-22 | — | — | WO | claimed |
| CN-1168443-C | Methods and compsns. for stimulating neurite growth using compounds with affinity for FKBP12 in combination with neurotrophic factors | ��̩��˹ҩ��ɷ�����˾ | 2004-09-29 | — | — | CN | disclosed |
| CN-1239434-A | Methods and compsns. for stimulating neurite growth using compounds with affinity for FKBP12 in combination with neurotrophic factors | VERTED PHARMACEUTICALS INC (US) | 1999-12-22 | — | — | CN | disclosed |