Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PNMT | P11086 | 4/20 | 0.41 |
| ▸ | TDP2 | O95551 | 1/20 | 0.37 |
| ▸ | KIF11 | P52732 | 5/20 | 0.36 |
| ▸ | METAP2 | P50579 | 1/20 | 0.34 |
| ▸ | PARP1 | P09874 | 1/20 | 0.34 |
| ▸ | PARP10 | Q53GL7 | 1/20 | 0.34 |
| ▸ | CHRNB2 | P17787 | 2/20 | 0.33 |
| ▸ | CHRNA4 | P43681 | 2/20 | 0.33 |
| ▸ | CHRNB4 | P30926 | 1/20 | 0.33 |
| ▸ | CHRNA3 | P32297 | 1/20 | 0.33 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.33 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
| ▸ | GAA | P10253 | 1/20 | 0.33 |
| ▸ | MAPT | P10636 | 1/20 | 0.33 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.33 |
| ▸ | HTR2A | P28223 | 1/20 | 0.33 |
| ▸ | HTR2C | P28335 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14332331 | 0.73 | AHR (0.42) | PNMTHTR2AHTR2CHTR2B | |
| SCHEMBL23037010 | 0.66 | KIF11 (0.46) | TDP2KIF11PARP1PARP10KMT2A | |
| SCHEMBL4991137 | 0.66 | PARP10 (0.56) | KIF11PARP1PARP10GAAHTR2A | |
| SCHEMBL4531599 | 0.63 | PNMT (0.44) | PNMTTDP2KIF11PARP1PARP10 | |
| SCHEMBL578303 | 0.63 | TDP2 (0.66) | TDP2KIF11GAA | |
| SCHEMBL31492431 | 0.63 | TDP2 (0.66) | TDP2KIF11GAA | |
| SCHEMBL2238253 | 0.63 | KIF11 (0.77) | TDP2KIF11 | |
| SCHEMBL3717613 | 0.63 | GAA (0.57) | KIF11PARP1PARP10ALDH1A1GAA | |
| SCHEMBL7385186 | 0.62 | GAA (0.52) | KIF11PARP1PARP10ALDH1A1GAA | |
| SCHEMBL22326600 | 0.62 | TDP2 (0.41) | PNMTTDP2KIF11PARP1PARP10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1670765-A2 | CETP INHIBITORS AND METABOLITES THEREOF | Pfizer Products Inc. (US) | 2006-06-21 | — | — | EP | disclosed |
| WO-2005033082-A2 | CETP INHIBITORS AND METABOLITES THEREOF | PFIZER PRODUCTS INC. (US) | 2005-04-14 | — | — | WO | disclosed |