Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TDP2 | O95551 | 2/20 | 0.66 |
| ▸ | KIF11 | P52732 | 12/20 | 0.65 |
| ▸ | AHR | P35869 | 2/20 | 0.56 |
| ▸ | GAA | P10253 | 2/20 | 0.54 |
| ▸ | PDE3B | Q13370 | 1/20 | 0.50 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.50 |
| ▸ | PDK2 | Q15119 | 1/20 | 0.48 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL31492431 | 1.00 | TDP2 (0.66) | TDP2KIF11AHRGAAPDE3B | |
| SCHEMBL1903306 | 0.88 | KIF11 (0.80) | TDP2KIF11AHRGAAPDE3B | |
| SCHEMBL2238253 | 0.86 | KIF11 (0.77) | TDP2KIF11 | |
| SCHEMBL3224720 | 0.86 | TDP2 (0.66) | TDP2KIF11AHRPDK2 | |
| SCHEMBL31734651 | 0.84 | TDP2 (0.54) | TDP2KIF11GAA | |
| SCHEMBL1907965 | 0.83 | KIF11 (0.66) | TDP2KIF11GAAPDE3BPDE3A | |
| SCHEMBL7138709 | 0.83 | KIF11 (0.80) | TDP2KIF11GAA | |
| SCHEMBL1902698 | 0.83 | KIF11 (0.59) | TDP2KIF11AHRGAAPDE3B | |
| SCHEMBL2054644 | 0.82 | AHR (0.56) | TDP2KIF11AHRGAAPDE3B | |
| SCHEMBL18189320 | 0.82 | KIF11 (0.58) | TDP2KIF11AHRGAAPDE3B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 123 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2025045835-A1 | PESTICIDALLY ACTIVE OXOINDOLE COMPOUNDS | SYNGENTA CROP PROTECTION AG (CH) | 2025-03-06 | — | — | WO | disclosed |
| CN-118974016-A | Indolone derivative and application thereof in medicine | 康百达（四川）生物医药科技有限公司 | 2024-11-15 | — | — | CN | disclosed |
| CN-111712491-B | Tetrahydroisoquinoline compounds, preparation method thereof, pharmaceutical composition containing compounds and application of compounds | 中国科学院上海药物研究所 | 2023-11-17 | — | — | CN | disclosed |
| WO-2023186137-A1 | INDOLINONE DERIVATIVE AND USE THEREOF IN MEDICINES | 成都百裕制药股份有限公司 | 2023-10-05 | — | — | WO | disclosed |
| US-RE47731-E1 | Kinase inhibitors and method of treating cancer with same | UNIV HEALTH NETWORK (CA) | 2019-11-19 | — | — | US | disclosed |
| US-10358436-B2 | Kinase inhibitors and method of treating cancer | UNIVERSITY HEALTH NETWORK (CA) | 2019-07-23 | — | — | US | disclosed |
| US-20180282306-A1 | KINASE INHIBITORS AND METHOD OF TREATING CANCER | UNIVERSITY HEALTH NETWORK (CA) | 2018-10-04 | — | — | US | disclosed |
| US-9907800-B2 | Kinase inhibitors and method of treating cancer | UNIVERSITY HEALTH NETWORK (CA) | 2018-03-06 | — | — | US | disclosed |
| US-20160045511-A1 | KINASE INHIBITORS AND METHOD OF TREATING CANCER | UNIVERSITY HEALTH NETWORK (CA) | 2016-02-18 | — | — | US | disclosed |
| EP-2694058-B1 | NEW INDOLINONE PROTEIN KINASE INHIBITORS | BETA PHARMA INC (US) | 2015-11-04 | — | — | EP | disclosed |
| US-4658037-A | RHEUMATIC DISEASES | PFIZER INC. (US) | 1987-04-14 | — | — | US | disclosed |
| US-4652658-A | Process for making 2-oxindole-1-carboxamides and intermediates therefor | PFIZER INC. (US) | 1987-03-24 | — | — | US | disclosed |
| EP-0175551-A1 | Analgesic and antiinflammatory 1,3-diacyl-2-oxindole compounds | PFIZER INC. (US) | 1986-03-26 | — | — | EP | disclosed |
| US-4569942-A | N,3-Disubstituted 2-oxindole-1-carboxamides as analgesic and antiinflammatory agents | PFIZER INC. (US) | 1986-02-11 | — | — | US | disclosed |
| EP-0164860-A1 | N,3-disubstituted 2-oxindole-1-carboxamides as analgesic and antiinflammatory agents | PFIZER INC. (US) | 1985-12-18 | — | — | EP | disclosed |
| US-4556672-A | 3-Substituted 2-oxindole-1-carboxamides as analgesic and anti-inflammatory agents | PFIZER INC. (US) | 1985-12-03 | — | — | US | disclosed |
| EP-0156603-A2 | 3-Substituted 2-oxindole-1-carboxamides as analgesic and anti-inflammatory agents | PFIZER INC. (US) | 1985-10-02 | — | — | EP | disclosed |
| EP-0155828-A2 | Process for making 2-oxindole-1-carboxamides and intermediates therefor | PFIZER INC. (US) | 1985-09-25 | — | — | EP | disclosed |
| EP-0153818-A2 | 1,3-Disubstituted 2-oxindoles as analgesic and anti-inflammatory agents | PFIZER INC. (US) | 1985-09-04 | — | — | EP | disclosed |
| US-4160032-A | Oxindoles as sleep-inducers | SANDOZ, INC. (US) | 1979-07-03 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20160045511-A1 | KINASE INHIBITORS AND METHOD OF TREATING CANCER | MAP3K6, MAP3K5, MAP3K19 | TDP2 1818/4885KIF11 671/4885AHR 4083/4885 |
| US-10358436-B2 | Kinase inhibitors and method of treating cancer | MAP3K6, MAP3K5, MAP3K19 | TDP2 1818/4885KIF11 671/4885AHR 4083/4885 |
| US-20180282306-A1 | KINASE INHIBITORS AND METHOD OF TREATING CANCER | MAP3K6, MAP3K5, MAP3K19 | TDP2 1818/4885KIF11 671/4885AHR 4083/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.