Known targets — ChEMBL curated mechanism
ACHEBDKRB2CHRM1CHRM2CHRM3CHRNA1CHRNB1CHRNDCHRNECHRNGGUCY1A1GUCY1A2GUCY1B1GUCY1B2NAMPTPTAFRSLC10A2SLC6A2SLC6A3TACR1dacAdacBdacCftsImrcAmrcBmrdA
The experimentally established mechanism targets of Hydrochloric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SIGMAR1 | Q99720 | 2/20 | 0.32 |
| ▸ | RET | P07949 | 1/20 | 0.32 |
| ▸ | HTR6 | P50406 | 1/20 | 0.31 |
| ▸ | HTR2A | P28223 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL1131735 | 0.79 | HTR2A (0.34) | SIGMAR1RETHTR6HTR2A | |
| Hydrochloric Acid SCHEMBL5695982 | 0.74 | BRD4 (0.37) | SIGMAR1RETHTR6HTR2A | |
| Hydrochloric Acid SCHEMBL137960 | 0.74 | HTR2A (0.39) | SIGMAR1RETHTR6HTR2A | |
| Hydrochloric Acid SCHEMBL29424565 | 0.74 | HTR2A (0.39) | SIGMAR1RETHTR6HTR2A | |
| Hydrochloric Acid SCHEMBL28189655 | 0.73 | BRD4 (0.36) | SIGMAR1RETHTR6HTR2A | |
| Hydrochloric Acid SCHEMBL820052 | 0.72 | HTR2A (0.38) | SIGMAR1RETHTR6HTR2A | |
| Hydrochloric Acid SCHEMBL30533388 | 0.72 | HTR2A (0.38) | SIGMAR1RETHTR6HTR2A | |
| Hydrochloric Acid SCHEMBL8681702 | 0.72 | SIGMAR1 (0.31) | SIGMAR1HTR6HTR2A | |
| SCHEMBL31357303 | 0.72 | HTR2A (0.40) | SIGMAR1RETHTR6HTR2A | |
| Hydrochloric Acid SCHEMBL1980401 | 0.72 | BRD4 (0.35) | SIGMAR1RETHTR6HTR2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1334107-B1 | NON-METALLOCENE COMPOUNDS, METHOD FOR THE PRODUCTION THEREOF AND USE OF THE SAME FOR THE POLYMERISATION OF OLEFINS | BASELL POLYOLEFINE GMBH (DE) | 2006-07-26 | — | — | EP | disclosed |