Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MRGPRX4 | Q96LA9 | 5/20 | 0.46 |
| ▸ | KDM1A | O60341 | 6/20 | 0.46 |
| ▸ | S1PR5 | Q9H228 | 1/20 | 0.45 |
| ▸ | ERN1 | O75460 | 1/20 | 0.45 |
| ▸ | LMNA | P02545 | 1/20 | 0.42 |
| ▸ | HTT | P42858 | 1/20 | 0.42 |
| ▸ | LIPE | Q05469 | 1/20 | 0.42 |
| ▸ | HTR2C | P28335 | 1/20 | 0.41 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.41 |
| ▸ | HTR2B | P41595 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 1/20 | 0.41 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.41 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.41 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.41 |
| ▸ | C5AR1 | P21730 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17024331 | 0.87 | MRGPRX4 (0.55) | MRGPRX4LIPEMAPTMAPK1TDP1 | |
| SCHEMBL17024333 | 0.85 | RXRA (0.56) | MRGPRX4S1PR5HTR2CSLC6A4HTR2B | |
| SCHEMBL17200641 | 0.81 | S1PR5 (0.44) | MRGPRX4S1PR5ERN1HTR2CSLC6A4 | |
| SCHEMBL17024339 | 0.77 | LMNA (0.58) | LMNAMAPTL3MBTL1 | |
| SCHEMBL1128800 | 0.77 | S1PR5 (0.52) | MRGPRX4KDM1AS1PR5ERN1LMNA | |
| SCHEMBL9434950 | 0.76 | HTR2C (0.48) | MRGPRX4LMNALIPEHTR2CSLC6A4 | |
| SCHEMBL11854600 | 0.76 | HTR2C (0.51) | MRGPRX4LMNALIPEHTR2CSLC6A4 | |
| SCHEMBL9631198 | 0.76 | MEN1 (0.53) | LMNAMAPTL3MBTL1 | |
| SCHEMBL224277 | 0.75 | KDM1A (0.55) | KDM1AS1PR5LMNAHTTSLC6A4 | |
| SCHEMBL30739242 | 0.75 | KDM1A (0.55) | KDM1AS1PR5LMNAHTTSLC6A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1675823-A1 | MEDICINAL COMPOUNDS | GLAXO GROUP LIMITED (GB) | 2006-07-05 | — | — | EP | disclosed |
| WO-2005040103-A1 | MEDICINAL COMPOUNDS | GLAXO GROUP LIMITED (GB) | 2005-05-06 | — | — | WO | disclosed |