Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE4A | P27815 | 1/20 | 0.39 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.39 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.39 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.39 |
| ▸ | PIN1 | Q13526 | 1/20 | 0.38 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.38 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.38 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.38 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.38 |
| ▸ | AR | P10275 | 1/20 | 0.38 |
| ▸ | EPAS1 | Q99814 | 4/20 | 0.37 |
| ▸ | VEGFA | P15692 | 1/20 | 0.36 |
| ▸ | PGR | P06401 | 1/20 | 0.35 |
| ▸ | TBXAS1 | P24557 | 1/20 | 0.35 |
| ▸ | FNTA | P49354 | 1/20 | 0.34 |
| ▸ | FNTB | P49356 | 1/20 | 0.34 |
| ▸ | PGGT1B | P53609 | 1/20 | 0.34 |
| ▸ | ENPP2 | Q13822 | 1/20 | 0.34 |
| ▸ | GRIA2 | P42262 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5697487 | 0.81 | AR (0.43) | PDE4APDE4BPDE4CPDE4DPIN1 | |
| SCHEMBL4155001 | 0.78 | PDE4A (0.40) | PDE4APDE4BPDE4CPDE4DMAP4K4 | |
| SCHEMBL8379001 | 0.77 | PDE4A (0.54) | PDE4APDE4BPDE4CPDE4DMAP4K4 | |
| SCHEMBL4154998 | 0.76 | PRSS1 (0.43) | PDE4APDE4BPDE4CPDE4DPIN1 | |
| SCHEMBL5697491 | 0.76 | MRGPRX1 (0.39) | PIN1MAP4K4SLC6A2SLC6A4SLC6A3 | |
| SCHEMBL27839327 | 0.75 | PDE4A (0.53) | PDE4APDE4BPDE4CPDE4DMAP4K4 | |
| SCHEMBL3230901 | 0.74 | PDE4A (0.41) | PDE4APDE4BPDE4CPDE4DMAP4K4 | |
| SCHEMBL5697484 | 0.74 | LTA4H (0.46) | PGR | |
| SCHEMBL10923033 | 0.74 | PDE4A (0.55) | PDE4APDE4BPDE4CPDE4DMAP4K4 | |
| SCHEMBL7186441 | 0.72 | PGR (0.55) | PDE4APDE4BPDE4CPDE4DMAP4K4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1669348-A1 | NOVEL ANTIFUNGAL AGENT COMPRISING HETEROCYCLIC COMPOUND | Eisai Co., Ltd. (JP) | 2006-06-14 | — | — | EP | disclosed |