Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RXRA | P19793 | 1/20 | 0.33 |
| ▸ | RXRB | P28702 | 1/20 | 0.33 |
| ▸ | ACE | P12821 | 5/20 | 0.33 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.33 |
| ▸ | IDO1 | P14902 | 2/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.32 |
| ▸ | MEN1 | O00255 | 1/20 | 0.32 |
| ▸ | LMNA | P02545 | 1/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.30 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.30 |
| ▸ | MAOA | P21397 | 1/20 | 0.30 |
| ▸ | ACHE | P22303 | 1/20 | 0.30 |
| ▸ | MAOB | P27338 | 1/20 | 0.30 |
| ▸ | NPC1 | O15118 | 1/20 | 0.30 |
| ▸ | RAB9A | P51151 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5698075 | 0.78 | ACE (0.39) | ACE | |
| SCHEMBL7342204 | 0.77 | — | — | |
| SCHEMBL5698147 | 0.77 | ACE (0.39) | ACEALDH1A1L3MBTL1 | |
| SCHEMBL5635258 | 0.72 | ALDH1A1 (0.42) | ALDH1A1 | |
| SCHEMBL4452654 | 0.71 | — | — | |
| SCHEMBL11435272 | 0.71 | DDB1 (0.41) | KMT2AALDH1A1L3MBTL1 | |
| SCHEMBL11228772 | 0.70 | SLC6A2 (0.34) | LMNAALDH1A1 | |
| SCHEMBL5698100 | 0.69 | ACE (0.40) | ACELMNAALDH1A1 | |
| SCHEMBL376160 | 0.68 | AKT1 (0.36) | L3MBTL1 | |
| SCHEMBL7313309 | 0.68 | FFAR4 (0.38) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0979817-B1 | LEUKOTRIENE A4 HYDROLAZE INHIBITORS | SANTEN PHARMACEUTICAL CO LTD (JP) | 2006-07-26 | — | — | EP | disclosed |
| US-6242476-B1 | Leukotriene A4 hydrolase inhibitors | SANTEN PHARMACEUTICAL CO., LTD. (JP) | 2001-06-05 | — | — | US | disclosed |
| EP-0979817-A1 | LEUKOTRIENE A 4? HYDROLAZE INHIBITORS | SANTEN PHARMACEUTICAL CO., LTD. (JP) | 2000-02-16 | — | — | EP | disclosed |