Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.42 |
| ▸ | DDB1 | Q16531 | 1/20 | 0.37 |
| ▸ | CRBN | Q96SW2 | 1/20 | 0.37 |
| ▸ | CTSB | P07858 | 2/20 | 0.36 |
| ▸ | CTSS | P25774 | 2/20 | 0.36 |
| ▸ | CTSK | P43235 | 2/20 | 0.36 |
| ▸ | CTSL | P07711 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11435272 | 0.86 | DDB1 (0.41) | ALDH1A1DDB1CRBN | |
| SCHEMBL8126802 | 0.85 | DDB1 (0.40) | ALDH1A1DDB1CRBN | |
| SCHEMBL6737982 | 0.85 | DDB1 (0.40) | ALDH1A1DDB1CRBN | |
| SCHEMBL376160 | 0.84 | AKT1 (0.36) | DDB1CRBNCTSL | |
| Hydrochloric Acid SCHEMBL5862748 | 0.84 | DDB1 (0.39) | ALDH1A1DDB1CRBN | |
| SCHEMBL7313309 | 0.82 | FFAR4 (0.38) | DDB1CRBN | |
| SCHEMBL9763836 | 0.81 | ALDH1A1 (0.40) | ALDH1A1DDB1CRBN | |
| SCHEMBL21874034 | 0.79 | KMT2A (0.37) | DDB1CRBN | |
| SCHEMBL8860733 | 0.79 | DDB1 (0.38) | ALDH1A1DDB1CRBN | |
| SCHEMBL1150970 | 0.78 | DDB1 (0.41) | ALDH1A1DDB1CRBNCTSBCTSS |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7205384-B2 | Process for preparing peptidyl heterocyclic ketone derivatives | ORTHO-MCNEIL PHARMACEUTICAL INC. (US) | 2007-04-17 | — | — | US | disclosed |
| US-7132418-B2 | Peptidyl heterocyclic ketones useful as tryptase inhibitors | ORTHO-MCNEIL PHARMACEUTICAL, INC. (US) | 2006-11-07 | — | — | US | disclosed |
| EP-1660493-A1 | PEPTIDYL HETEROCYCLIC KETONE DERIVATIVES AND PREPARATION PROCESSES | JANSSEN PHARMACEUTICA N.V. (BE) | 2006-05-31 | — | — | EP | disclosed |
| WO-2005023804-A1 | PEPTIDYL HETEROCYCLIC KETONE DERIVATIVES AND PREPARATION PROCESSES | JANSSEN PHARMACEUTICA, N.V. (BE) | 2005-03-17 | — | — | WO | disclosed |
| US-20050059607-A1 | Process for preparing peptidyl heterocyclic ketone derivatives | JANSSEN PHARMACEUTICA, N.V. (BE) | 2005-03-17 | — | — | US | disclosed |
| US-20030008829-A1 | Peptidyl heterocyclic ketones useful as tryptase inhibitors | COSTANZO MICHAEL J (US) | 2003-01-09 | — | — | US | disclosed |
| US-6469036-B1 | PREVENTION AND TREATMENT OF INFLAMMATORY DISEASES ASSOCIATED WITH THE RESPIRATORY TRACT, SUCH AS ASTHMA AND ALLERGIC RHINITIS | ORTHO-MCNEIL PHARMACEUTICAL, INC. | 2002-10-22 | — | — | US | disclosed |
| EP-1147097-A1 | PEPTIDYL HETEROCYCLIC KETONES USEFUL AS TRYPTASE INHIBITORS | Ortho-Mcneil Pharmaceutical, Inc. (US) | 2001-10-24 | — | — | EP | disclosed |
| WO-2000044733-A1 | PEPTIDYL HETEROCYCLIC KETONES USEFUL AS TRYPTASE INHIBITORS | ORTHO-MCNEIL PHARMACEUTICAL, INC. (US) | 2000-08-03 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050059607-A1 | Process for preparing peptidyl heterocyclic ketone derivatives | CMA1, TPSB2, TPSAB1 | ALDH1A1 1574/4885DDB1 4789/4885CRBN 1531/4885 |
| US-20030008829-A1 | Peptidyl heterocyclic ketones useful as tryptase inhibitors | CMA1, TPSB2, TPSAB1 | ALDH1A1 1904/4885DDB1 3876/4885CRBN 1709/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.