Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGS2 | P35354 | 10/20 | 0.59 |
| ▸ | PTGS1 | P23219 | 4/20 | 0.55 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.38 |
| ▸ | KIF11 | P52732 | 6/20 | 0.36 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.34 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.34 |
| ▸ | OPRL1 | P41146 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4362915 | 0.82 | OPRM1 (0.40) | KIF11OPRM1OPRL1 | |
| SCHEMBL16622528 | 0.82 | OPRM1 (0.40) | KIF11OPRM1OPRL1 | |
| SCHEMBL6687073 | 0.81 | PTGS2 (0.56) | PTGS2PTGS1MAPK14 | |
| SCHEMBL5698516 | 0.80 | PTGS2 (0.54) | PTGS2PTGS1MAPK14 | |
| SCHEMBL5698535 | 0.75 | PTGS2 (0.58) | PTGS2PTGS1 | |
| SCHEMBL8993560 | 0.75 | PTGS2 (0.34) | PTGS2PTGS1MAPK14 | |
| SCHEMBL215443 | 0.74 | PTGS2 (1.00) | PTGS2PTGS1 | |
| SCHEMBL8654658 | 0.73 | PTGS2 (0.58) | PTGS2PTGS1MAPK14KIF11CYP1A2 | |
| SCHEMBL8371975 | 0.72 | PTGS2 (0.44) | PTGS2PTGS1 | |
| SCHEMBL8651596 | 0.71 | PTGS2 (1.00) | PTGS2PTGS1KIF11 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1682143-A2 | COMBINATIONS COMPRISING AN HSP90 INHIBITOR AND A PHOPHODIESTERASE INHIBITOR FOR TREATING OR PREVENTING NEOPLASIA | Pharmacia Corporation (US) | 2006-07-26 | — | — | EP | disclosed |
| WO-2005041879-A2 | COMBINATIONS COMPRISING AN Hsp90 INHIBITOR AND A PHOPHODIESTERASE INHIBITOR FOR TREATING OR PREVENTING NEOPLASIA | PHARMACIA CORPORATION (US) | 2005-05-12 | — | — | WO | disclosed |
| EP-1283723-A2 | COMBINATION THERAPY USING COX-2 SELECTIVE INHIBITOR AND THROMBOXANE INHIBITOR AND COMPOSITIONS THEREFOR | Merck Frosst Canada & Co. (CA) | 2003-02-19 | — | — | EP | disclosed |
| WO-2001087343-A2 | COMBINATION THERAPY USING COX-2 SELECTIVE INHIBITOR AND THROMBOXANE INHIBITOR AND COMPOSITIONS THEREFOR | MERCK FROSST CANADA & CO. (CA) | 2001-11-22 | — | — | WO | disclosed |