Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGS2 | P35354 | 18/20 | 0.56 |
| ▸ | PTGS1 | P23219 | 6/20 | 0.56 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5698507 | 0.84 | PTGS2 (0.64) | PTGS2PTGS1MAPK14 | |
| SCHEMBL5698516 | 0.84 | PTGS2 (0.54) | PTGS2PTGS1MAPK14 | |
| SCHEMBL5698458 | 0.81 | PTGS2 (0.59) | PTGS2PTGS1MAPK14 | |
| SCHEMBL444633 | 0.80 | ACHE (0.41) | — | |
| SCHEMBL14467510 | 0.80 | ACHE (0.41) | — | |
| SCHEMBL5698535 | 0.79 | PTGS2 (0.58) | PTGS2PTGS1 | |
| SCHEMBL8993560 | 0.79 | PTGS2 (0.34) | PTGS2PTGS1MAPK14 | |
| SCHEMBL8371975 | 0.76 | PTGS2 (0.44) | PTGS2PTGS1 | |
| SCHEMBL8266062 | 0.75 | MAPK14 (0.62) | PTGS2PTGS1MAPK14 | |
| SCHEMBL8389316 | 0.72 | MAPK14 (0.64) | PTGS2PTGS1MAPK14 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2004096206-A2 | THERAPEUTIC COMBINATION OF A COX-2 INHIBITOR AND A TACE INHIBITOR | PHARMACIA CORPORATION (US) | 2004-11-11 | — | — | WO | disclosed |