SCHEMBL569917

SCHEMBL569917

O=C(O)c1cc2ncccn2n1

nearest known ligand 1.00 ✓ in ChEMBL — recovers established targets

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
APOBEC3A P31941 3/20 1.00
APOBEC3G Q9HC16 2/20 1.00
KDM4E B2RXH2 11/20 0.48
TDP1 Q9NUW8 1/20 0.46
HTR2A P28223 1/20 0.43
HTR2C P28335 1/20 0.43
L3MBTL1 Q9Y468 4/20 0.41
LMNA P02545 2/20 0.41
NAPRT Q6XQN6 1/20 0.41
P4HTM Q9NXG6 1/20 0.41
GFER P55789 1/20 0.41
ALDH1A1 P00352 6/20 0.40
GAA P10253 4/20 0.40
MGLL Q99685 2/20 0.40
POLB P06746 2/20 0.40
NTRK1 P04629 2/20 0.38
AURKA O14965 1/20 0.38
DAPK3 O43293 1/20 0.38
JAK2 O60674 1/20 0.38
MAP4K4 O95819 1/20 0.38

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL13995847 0.84 APOBEC3A (0.73) APOBEC3AAPOBEC3GKDM4EHTR2AHTR2C
SCHEMBL14249152 0.84 APOBEC3A (0.73) APOBEC3AAPOBEC3GKDM4EHTR2AHTR2C
SCHEMBL4312244 0.80 APOBEC3A (0.67) APOBEC3AAPOBEC3GKDM4ETDP1HTR2A
SCHEMBL4250069 0.80 APOBEC3A (0.67) APOBEC3AAPOBEC3GKDM4ETDP1HTR2A
SCHEMBL17883352 0.80 APOBEC3A (0.67) APOBEC3AAPOBEC3GKDM4EHTR2AHTR2C
SCHEMBL17321385 0.80 APOBEC3A (0.67) APOBEC3AAPOBEC3GKDM4ETDP1HTR2A
SCHEMBL7048077 0.79 APOBEC3A (0.65) APOBEC3AAPOBEC3GKDM4EHTR2AHTR2C
SCHEMBL17460426 0.78 APOBEC3A (0.62) APOBEC3AAPOBEC3GHTR2AHTR2CGFER
SCHEMBL4794765 0.77 APOBEC3A (0.61) APOBEC3AAPOBEC3GKDM4EHTR2AHTR2C
SCHEMBL4428625 0.77 APOBEC3A (0.61) APOBEC3AAPOBEC3GKDM4ETDP1HTR2A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 102 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-3856179-B1 MONOACYLGLYCEROL LIPASE MODULATORS JANSSEN PHARMACEUTICA NV (BE) 2026-05-13 EP disclosed
EP-3710428-B1 MODULATORS OF THE INTEGRATED STRESS PATHWAY CALICO LIFE SCIENCES LLC (US) 2026-03-25 EP disclosed
US-20250313574-A1 SIALIC ACID DERIVATIVES AND METHODS OF USING SAME EISAI R&D MANAGEMENT CO., LTD. (JP) 2025-10-09 US disclosed
US-20250161307-A1 PYRAZOLOPYRIMIDINES AS MODULATORS OF SPERMINE OXIDASE JANSSEN PHARMACEUTICA NV (BE) 2025-05-22 US disclosed
WO-2025087365-A1 METTL3 INHIBITOR 杭州邦顺制药有限公司 2025-05-01 WO disclosed
CN-119899188-A METTL3 inhibitors 杭州邦顺制药有限公司 2025-04-29 CN disclosed
EP-4540242-A1 COMPOUNDS AND PHARMACEUTICAL COMPOSITIONS THAT DEGRADE SWI/SNF-RELATED MATRIX-ASSOCIATED ACTIN-DEPENDENT REGULATOR OF CHROMATIN SUBFAMILY A Plexium, Inc. (US) 2025-04-23 EP disclosed
EP-4536653-A2 SIALIC ACID DERIVATIVES AND METHODS OF USING SAME Eisai R&D Management Co., Ltd. (JP) 2025-04-16 EP disclosed
CN-119654318-A Compounds and pharmaceutical compositions for degrading SWI/SNF-associated matrix-associated actin-dependent chromatin subfamily A modulators 普莱克斯姆公司 2025-03-18 CN disclosed
EP-4469454-A1 PYRAZOLOPYRIMIDINES AS MODULATORS OF SPERMINE OXIDASE Janssen Pharmaceutica NV (BE) 2024-12-04 EP disclosed
WO-2010096115-A1 COMPOUNDS, COMPOSITIONS AND METHODS FOR CONTROL OF HEPATITIS C VIRAL INFECTIONS APATH, LLC (US) 2010-08-26 WO disclosed
US-20100099683-A1 COMPOUNDS THAT INHIBIT HUMAN DNA LIGASES AND METHODS OF TREATING CANCER NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT 2010-04-22 US disclosed
US-20100099683-A1 COMPOUNDS THAT INHIBIT HUMAN DNA LIGASES AND METHODS OF TREATING CANCER NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT 2010-04-22 US disclosed
US-20100041638-A1 Chemical Compounds 293 ASTRAZENECA AB (SE) 2010-02-18 US disclosed
WO-2009144494-A1 PHENOXYPYRIDINYLAMIDE DERIVATIVES AND THEIR USE IN THE TREATMENT OF PDE4 MEDIATED DISEASE STATES ASTRAZENECA AB (SE) 2009-12-03 WO disclosed
EP-1309565-B1 HETEROCYCLIC MUTILIN ESTERS AND THEIR USE AS ANTIBACTERIALS SMITHKLINE BEECHAM PLC (GB) 2008-04-09 EP disclosed
US-6878704-B2 Heterocyclic mutilin esters and their use as antibacterials SMITHKLINE BEECHAM P.L.C. (GB) 2005-04-12 US disclosed
US-20040058937-A1 Heterocyclic mutilin esters and their use as antibacterials SMITHKLINE BEECHAM P.L.C. (GB) 2004-03-25 US disclosed
EP-1309565-A1 HETEROCYCLIC MUTILIN ESTERS AND THEIR USE AS ANTIBACTERIALS SMITHKLINE BEECHAM PLC (GB) 2003-05-14 EP disclosed
WO-2002012199-A1 HETEROCYCLIC MUTILIN ESTERS AND THEIR USE AS ANTIBACTERIALS SMITHKLINE BEECHAM P.L.C. (GB) 2002-02-14 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20040058937-A1 Heterocyclic mutilin esters and their use as antibacterials MLN, MSH2, MRPL21 APOBEC3A 3459/4885APOBEC3G 3856/4885KDM4E 4142/4885
US-20100041638-A1 Chemical Compounds 293 PDE4B, PDE4A, PDE3B APOBEC3A 4668/4885APOBEC3G 4524/4885KDM4E 778/4885
US-20100099683-A1 COMPOUNDS THAT INHIBIT HUMAN DNA LIGASES AND METHODS OF TREATING CANCER LIG1, LIG4, LIG3 APOBEC3A 383/4885APOBEC3G 439/4885KDM4E 1696/4885
US-20250313574-A1 SIALIC ACID DERIVATIVES AND METHODS OF USING SAME NEU1, NEU2, NEU4 APOBEC3A 1079/4885APOBEC3G 721/4885KDM4E 4207/4885
US-20250161307-A1 PYRAZOLOPYRIMIDINES AS MODULATORS OF SPERMINE OXIDASE SMOX, SRM, SMS APOBEC3A 2514/4885APOBEC3G 3180/4885KDM4E 1480/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.