Mometasone Furoate

SCHEMBL570073

CC(=O)OCC(=O)[C@@]1(O)[C@H](C)C[C@H]2[C@@H]3CCC4=CC(=O)C=C[C@]4(C)[C@@]3(F)C(O)C[C@@]21C.C[C@@H]1C[C@H]2[C@@H]3CCC4=CC(=O)C=C[C@]4(C)[C@@]3(Cl)[C@@H](O)C[C@]2(C)[C@@]1(OC(=O)c1ccco1)C(=O)CCl

nearest known ligand 0.77

Full drug profile on Sugi Atlas →

Known targets — ChEMBL curated mechanism

NR3C1

The experimentally established mechanism targets of Mometasone Furoate. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.

Predicted protein targets (top 20)

	gene	UniProt	supporting neighbours	confidence
▸	NR3C1 known ✓	P04150	6/20	0.77

▸	CYP3A4	P08684	6/20	0.77

▸	LMNA	P02545	4/20	0.77

▸	CYP2C9	P11712	3/20	0.77

▸	ABCB11	O95342	3/20	0.77

▸	PGR	P06401	3/20	0.77

▸	CYP2D6	P10635	2/20	0.77

▸	ADORA3	P0DMS8	2/20	0.77

▸	CYP1A2	P05177	1/20	0.77

▸	CYP2C19	P33261	1/20	0.77

▸	AR	P10275	1/20	0.77

▸	PTGS1	P23219	1/20	0.77

▸	SLCO1B3	Q9NPD5	1/20	0.77

▸	SLCO1B1	Q9Y6L6	1/20	0.77

▸	HIF1A	Q16665	4/20	0.67

▸	SMN1; SMN2	Q16637	2/20	0.67

▸	CNR1	P21554	1/20	0.67

▸	TBXA2R	P21731	1/20	0.67

▸	USP2	O75604	3/20	0.60

▸	NR1I2	O75469	2/20	0.60

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compound	similarity	top predicted	shared targets
Dexamethasone Acefurate SCHEMBL139744	0.89	NR3C1 (0.69)	CYP3A4NR3C1LMNACYP2C9ABCB11
Mometasone Furoate SCHEMBL6414123	0.89	CYP3A4 (0.84)	CYP3A4NR3C1LMNACYP2C9ABCB11
Amcinonide SCHEMBL18116084	0.89	CYP3A4 (0.70)	CYP3A4NR3C1LMNACYP2C9ABCB11
SCHEMBL11037205	0.89	NR3C1 (0.83)	CYP3A4NR3C1LMNACYP2C9ABCB11
Mometasone Furoate SCHEMBL25382496	0.88	CYP3A4 (1.00)	CYP3A4NR3C1LMNACYP2C9ABCB11
Mometasone Furoate SCHEMBL7436523	0.88	CYP3A4 (1.00)	CYP3A4NR3C1LMNACYP2C9ABCB11
Mometasone Furoate SCHEMBL8430908	0.88	CYP3A4 (1.00)	CYP3A4NR3C1LMNACYP2C9ABCB11
Mometasone Furoate SCHEMBL13026146	0.88	CYP3A4 (1.00)	CYP3A4NR3C1LMNACYP2C9ABCB11
Mometasone Furoate SCHEMBL4568	0.88	CYP3A4 (1.00)	CYP3A4NR3C1LMNACYP2C9ABCB11
Mometasone Furoate SCHEMBL4896227	0.88	CYP3A4 (1.00)	CYP3A4NR3C1LMNACYP2C9ABCB11

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

Patent	Title	Assignee	Published	Priority	Filing	Country	Status
WO-2012017370-A1	A MEDICINAL FUSIDIC ACID CREAM MADE USING SODIUM FUSIDATE AND INCORPORATING A BIOPOLYMER, BETAMETHASONE DIPROPIONATE, TERBINAFINE HYDROCHLORIDE AND A PROCESS TO MAKE IT	VANANGAMUDI SULUR SUBRAMANIAM (IN)	2012-02-09	—	—	WO	disclosed