Dexamethasone Acefurate

Dexamethasone Acefurate

SCHEMBL139744

CC(=O)OCC(=O)[C@@]1(OC(=O)c2ccco2)[C@H](C)C[C@H]2[C@@H]3CCC4=CC(=O)C=C[C@]4(C)[C@@]3(F)[C@@H](O)C[C@@]21C

nearest known ligand 0.69

Full drug profile on Sugi Atlas →

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
▸ NR3C1 P04150 9/20 0.69
▸ PGR P06401 6/20 0.69
▸ MAPT P10636 3/20 0.69
▸ ADORA3 P0DMS8 2/20 0.69
▸ NR1I2 O75469 2/20 0.69
▸ DRD2 P14416 1/20 0.69
▸ OPRD1 P41143 1/20 0.69
▸ CYP3A4 P08684 9/20 0.69
▸ LMNA P02545 5/20 0.69
▸ CYP2C9 P11712 3/20 0.69
▸ CYP1A2 P05177 2/20 0.69
▸ AR P10275 2/20 0.69
▸ CYP2D6 P10635 2/20 0.69
▸ ABCB11 O95342 2/20 0.69
▸ CYP2C19 P33261 1/20 0.69
▸ PTGS1 P23219 1/20 0.69
▸ SLCO1B3 Q9NPD5 1/20 0.69
▸ SLCO1B1 Q9Y6L6 1/20 0.69
▸ HIF1A Q16665 5/20 0.68
▸ SMN1; SMN2 Q16637 3/20 0.68

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL11249101 0.92 NR3C1 (0.72) NR3C1PGRMAPTADORA3NR1I2
SCHEMBL11251406 0.92 NR3C1 (0.72) NR3C1PGRMAPTADORA3NR1I2
SCHEMBL11037864 0.92 NR3C1 (0.72) NR3C1PGRADORA3CYP3A4LMNA
SCHEMBL4102916 0.92 NR3C1 (0.72) NR3C1PGRADORA3CYP3A4LMNA
SCHEMBL11037205 0.91 NR3C1 (0.83) NR3C1PGRMAPTADORA3NR1I2
SCHEMBL11081794 0.91 NR3C1 (0.68) NR3C1PGRMAPTADORA3NR1I2
Mometasone Furoate SCHEMBL570073 0.89 CYP3A4 (0.77) NR3C1PGRMAPTADORA3NR1I2
SCHEMBL4003694 0.89 NR3C1 (0.68) NR3C1PGRMAPTADORA3NR1I2
SCHEMBL4224907 0.89 NR3C1 (0.68) NR3C1PGRMAPTADORA3NR1I2
SCHEMBL4003695 0.88 NR3C1 (0.67) NR3C1PGRMAPTADORA3NR1I2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 259 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20250295608-A1 PHARMACEUTICAL COMPOSITIONS AND METHODS FOR TREATING OSTEOARTHRITIS INSIGNIA PHARMACEUTICALS, LLC (US) 2025-09-25 — — US claimed
US-20250288599-A1 PHARMACEUTICAL COMPOSITIONS AND METHODS FOR TREATING OSTEOARTHRITIS INSIGNIA PHARMACEUTICALS, LLC (US) 2025-09-18 — — US claimed
EP-3993715-B1 IMPLANTATION NEEDLE FOR INSERTING A SUBCUTANEOUSLY INSERTABLE ELEMENT INTO A BODY TISSUE HOFFMANN LA ROCHE (CH) 2024-04-17 — — EP claimed
US-20230210868-A1 Methods of Treatment Using ICAM-Modulating Agents AVM BIOTECHNOLOGY, LLC (US) 2023-07-06 — — US claimed
EP-2794008-A1 COMBINATION ANTI-INFLAMMATORY OPHTHALMIC COMPOSITIONS Insite Vision Incorporated (US) 2014-10-29 — — EP claimed
US-20130165419-A1 COMBINATION ANTI-INFLAMMATORY OPHTHALMIC COMPOSITIONS INSITE VISION INCORPORATED 2013-06-27 — — US claimed
WO-2013096857-A1 COMBINATION ANTI-INFLAMMATORY OPHTHALMIC COMPOSITIONS INSITE VISION INCORPORATED (US) 2013-06-27 — — WO claimed
EP-1336602-A1 Nitrate prodrugs able to release nitric oxide in a controlled and selective way and their use for prevention and treatment of inflammatory, ischemic and proliferative diseases Scaramuzzino, Giovanni (IT) 2003-08-20 — — EP claimed
US-20260124244-A1 MEGAKARYOCYTE DERIVATIVES FOR TREATMENT OF DRY EYE DISEASES STELLULAR BIO, INC. (US) 2026-05-07 — — US disclosed
EP-4646217-A1 MEGAKARYOCYTE DERIVATIVES FOR TREATMENT OF DRY EYE DISEASES Stellular Bio, Inc. (US) 2025-11-12 — — EP disclosed
US-20240423907-A1 Improved Nasal Administration of Pharmaceutical Formulations CYRANO THERAPEUTICS, INC. 2024-12-26 — — US disclosed
EP-4476217-A1 MORPHIC FORMS OF CFT7455 AND METHODS OF MANUFACTURE THEREOF C4 Therapeutics, Inc. (US) 2024-12-18 — — EP disclosed
US-20240391912-A1 MORPHIC FORMS OF CFT7455 AND METHODS OF MANUFACTURE THEREOF C4 THERAPEUTICS, INC. (US) 2024-11-28 — — US disclosed
EP-4460284-A1 IMPROVED NASAL ADMINISTRATION OF PHARMACEUTICAL FORMULATIONS Cyrano Therapeutics, Inc. (US) 2024-11-13 — — EP disclosed
WO-2002045693-A1 PHARMACEUTICAL PREPARATION COMPRISING AN ACTIVE DISPERSED ON A MATRIX ALTANA PHARMA AG (DE) 2002-06-13 — — WO disclosed
US-6331289-B1 ULTRASOUND CONTRAST AGENTS, SUSPENSION IN AQUEOUS CARRIER LIQUID OF A REPORTER COMPRISING GAS-CONTAINING OR GAS-GENERATING MATERIAL, AGENT CAPABLE OF FORMING AT LEAST TWO TYPES OF BINDING PAIRS WITH TARGET; REPORTER BEING CONJUGATED NYCOMED IMAGING AS (NO) 2001-12-18 — — US disclosed
US-6264917-B1 MIXTURE OF GAS FILLED MICROBUBBLES AND RELEASING AGENT NYCOMED IMAGING AS (NO) 2001-07-24 — — US disclosed
US-6261537-B1 TARGETS AND ULTRASOUND DIAGNOSIS OF ACTIVE MATERIALS, AQUEOUS CARRIER LIQUIDS, CARRIERS AND FILM FORMING SURFACTANT PHOSPHATIDES NYCOMED IMAGING AS (NO) 2001-07-17 — — US disclosed
US-20010002404-A1 Fatty acid-pharmaceutical agent conjugates LUITPOLD PHARMACEUTICALS, INC. 2001-05-31 — — US disclosed
WO-1999030690-A1 ORAL DELIVERY FORMULATION AXIA THERAPEUTICS, INC. (US) 1999-06-24 — — WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20130165419-A1 COMBINATION ANTI-INFLAMMATORY OPHTHALMIC COMPOSITIONS PTGS1, TNF, PTGES NR3C1 209/4885PGR 749/4885MAPT 2890/4885
US-20010002404-A1 Fatty acid-pharmaceutical agent conjugates FABP7, FFAR2, FFAR4 NR3C1 1759/4885PGR 3268/4885MAPT 1592/4885
US-20260124244-A1 MEGAKARYOCYTE DERIVATIVES FOR TREATMENT OF DRY EYE DISEASES MYH10, PDGFA, MPL NR3C1 4364/4885PGR 157/4885MAPT 1935/4885
US-20240391912-A1 MORPHIC FORMS OF CFT7455 AND METHODS OF MANUFACTURE THEREOF CLINT1, UGT1A1, DNM1 NR3C1 2180/4885PGR 4351/4885MAPT 436/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.

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