Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ROCK2 | O75116 | 4/20 | 0.54 |
| ▸ | ROCK1 | Q13464 | 4/20 | 0.54 |
| ▸ | TAS1R3 | Q7RTX0 | 2/20 | 0.51 |
| ▸ | TAS1R1 | Q7RTX1 | 2/20 | 0.51 |
| ▸ | TNF | P01375 | 3/20 | 0.49 |
| ▸ | LMNA | P02545 | 2/20 | 0.48 |
| ▸ | MAPT | P10636 | 1/20 | 0.48 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.48 |
| ▸ | HPGD | P15428 | 1/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.46 |
| ▸ | MEN1 | O00255 | 1/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.44 |
| ▸ | PDE4A | P27815 | 2/20 | 0.44 |
| ▸ | PDE4B | Q07343 | 2/20 | 0.44 |
| ▸ | PDE4C | Q08493 | 2/20 | 0.44 |
| ▸ | PDE4D | Q08499 | 2/20 | 0.44 |
| ▸ | ANPEP | P15144 | 1/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.43 |
| ▸ | FLT3 | P36888 | 1/20 | 0.43 |
| ▸ | NR1H4 | Q96RI1 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5700841 | 1.00 | ROCK2 (0.54) | ROCK2ROCK1TAS1R3TAS1R1TNF | |
| SCHEMBL7876199 | 0.93 | HPGD (0.52) | ROCK2ROCK1TAS1R3TAS1R1TNF | |
| SCHEMBL7867559 | 0.85 | ITGB3 (0.49) | ROCK2ROCK1TAS1R3TAS1R1TNF | |
| SCHEMBL5700999 | 0.83 | MAPT (0.49) | ROCK2ROCK1LMNAMAPTALDH1A1 | |
| SCHEMBL5701002 | 0.83 | MAPT (0.49) | ROCK2ROCK1LMNAMAPTALDH1A1 | |
| SCHEMBL5700932 | 0.81 | MEN1 (0.60) | ROCK2ROCK1LMNAMAPTMEN1 | |
| SCHEMBL5700925 | 0.81 | MEN1 (0.60) | ROCK2ROCK1LMNAMAPTMEN1 | |
| SCHEMBL7876448 | 0.81 | POLB (0.58) | ROCK2ROCK1TAS1R3TAS1R1TNF | |
| SCHEMBL7872607 | 0.80 | TAS1R3 (0.53) | ROCK2ROCK1TAS1R3TAS1R1TNF | |
| SCHEMBL15595838 | 0.78 | TAS1R3 (0.55) | TAS1R3TAS1R1LMNAMAPTHPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1027328-B1 | SUBSTITUTED ANILIDES | AVENTIS PHARMA LTD (GB) | 2006-08-23 | — | — | EP | disclosed |
| US-6479519-B1 | INHIBITORS OF CELL ADHESION; TREATMENT OF ASTHMA OR INFLAMMATORY BOWEL DISEASE | AVENTIS PHARMA LIMITED (GB) | 2002-11-12 | — | — | US | disclosed |