Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GAA | P10253 | 1/20 | 0.32 |
| ▸ | MAOA | P21397 | 1/20 | 0.32 |
| ▸ | MAOB | P27338 | 1/20 | 0.32 |
| ▸ | MEN1 | O00255 | 1/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.32 |
| ▸ | RET | P07949 | 1/20 | 0.30 |
| ▸ | HTR2A | P28223 | 2/20 | 0.30 |
| ▸ | SLC6A4 | P31645 | 2/20 | 0.30 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15211210 | 0.80 | KDM4E (0.37) | GAAMAOAMAOBMEN1KMT2A | |
| SCHEMBL5763251 | 0.80 | CYP1A2 (0.35) | GAAMEN1KMT2A | |
| SCHEMBL4620778 | 0.80 | — | — | |
| SCHEMBL480070 | 0.78 | SLC6A4 (0.43) | MEN1KMT2AHTR2ASLC6A4KCNH2 | |
| SCHEMBL6179860 | 0.76 | SMN1; SMN2 (0.36) | SLC6A4 | |
| SCHEMBL14793788 | 0.73 | L3MBTL1 (0.44) | GAAMAOAMAOBMEN1KMT2A | |
| SCHEMBL5702339 | 0.72 | HTR2A (0.30) | HTR2ASLC6A4KCNH2 | |
| SCHEMBL5747779 | 0.72 | MAOA (0.40) | MAOAMAOBMEN1KMT2AHTR2A | |
| SCHEMBL25396490 | 0.71 | SLC6A4 (0.39) | MEN1KMT2AHTR2ASLC6A4KCNH2 | |
| SCHEMBL4428218 | 0.71 | MEN1 (0.36) | MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1673366-A1 | 1-\"2-(4-HYDROXYPHENYL)-2-HYDROXYETHYL]-PIPERIDIN-4-OL COMPOUNDS AS NMDA RECEPTOR ANTAGONISTS | Pfizer, Inc. (US) | 2006-06-28 | — | — | EP | disclosed |
| WO-2005035522-A1 | 1-‘2-(4-HYDROXYPHENYL)-2-HYDROXYETHYL!-PIPERIDIN-4-OL COMPOUNDS AS NMDA RECEPTOR ANTAGONISTS | PFIZER JAPAN, INC. (JP) | 2005-04-21 | — | — | WO | disclosed |