Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LPL | P06858 | 2/20 | 0.47 |
| ▸ | LIPG | Q9Y5X9 | 2/20 | 0.47 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.45 |
| ▸ | GAA | P10253 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.40 |
| ▸ | VCAM1 | P19320 | 3/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.40 |
| ▸ | POLB | P06746 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
| ▸ | SERPINE1 | P05121 | 1/20 | 0.39 |
| ▸ | TSHR | P16473 | 1/20 | 0.39 |
| ▸ | ESR1 | P03372 | 1/20 | 0.38 |
| ▸ | CNR2 | P34972 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20245217 | 0.82 | TDP1 (0.47) | TDP1GAAALDH1A1KDM4EVCAM1 | |
| SCHEMBL5706226 | 0.81 | HDAC3 (0.57) | LPLLIPGTDP1ALDH1A1SMN1; SMN2 | |
| SCHEMBL29956809 | 0.78 | RAB9A (0.51) | ALDH1A1KDM4ESMN1; SMN2MAPT | |
| SCHEMBL957571 | 0.78 | RAB9A (0.51) | ALDH1A1KDM4ESMN1; SMN2MAPT | |
| SCHEMBL5190090 | 0.78 | TDP1 (0.71) | TDP1GAAALDH1A1MAPTESR1 | |
| SCHEMBL2317288 | 0.77 | ALDH1A1 (0.65) | GAAALDH1A1KDM4EHSD17B10SMN1; SMN2 | |
| SCHEMBL20314705 | 0.77 | PGR (0.51) | TDP1ESR1 | |
| SCHEMBL20245175 | 0.76 | MCOLN3 (0.52) | TDP1GAAVCAM1SMN1; SMN2POLB | |
| SCHEMBL14320162 | 0.74 | SLC6A2 (0.58) | TDP1VCAM1SMN1; SMN2POLBMAPT | |
| SCHEMBL16014803 | 0.74 | LPL (0.59) | LPLLIPGCNR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1562961-B1 | HALO SULFONYL ARYL BORONATES | NOVO NORDISK AS (DK) | 2006-10-25 | — | — | EP | disclosed |
| EP-1562961-A1 | HALO SULFONYL ARYL BORONATES | NOVO NORDISK A/S (DK) | 2005-08-17 | — | — | EP | disclosed |
| US-6872849-B2 | Halo sulfonyl aryl boronates | NOVO NORDISK A/S (DK) | 2005-03-29 | — | — | US | disclosed |
| US-20040116701-A1 | Halo sulfonyl aryl boronates | NOVO NORDISK A/S (DK) | 2004-06-17 | — | — | US | disclosed |
| WO-2004041833-A1 | HALO SULFONYL ARYL BORONATES | NOVO NORDISK A/S (DK) | 2004-05-21 | — | — | WO | disclosed |