Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | F11 | P03951 | 3/20 | 0.34 |
| ▸ | F2 | P00734 | 2/20 | 0.33 |
| ▸ | PRSS1 | P07477 | 2/20 | 0.33 |
| ▸ | PRSS2 | P07478 | 2/20 | 0.33 |
| ▸ | PRSS3 | P35030 | 2/20 | 0.33 |
| ▸ | CDC7 | O00311 | 1/20 | 0.32 |
| ▸ | LPL | P06858 | 3/20 | 0.32 |
| ▸ | LIPG | Q9Y5X9 | 3/20 | 0.32 |
| ▸ | HIF1A | Q16665 | 2/20 | 0.31 |
| ▸ | SIRT3 | Q9NTG7 | 1/20 | 0.30 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.30 |
| ▸ | BRD4 | O60885 | 1/20 | 0.30 |
| ▸ | PKM | P14618 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22468534 | 0.89 | LIPG (0.39) | F11F2PRSS1PRSS2PRSS3 | |
| SCHEMBL7046117 | 0.83 | F11 (0.31) | F11F2PRSS1PRSS2PRSS3 | |
| SCHEMBL1291127 | 0.82 | F11 (0.35) | F11F2PRSS1PRSS2PRSS3 | |
| SCHEMBL28507189 | 0.80 | F11 (0.35) | F11F2PRSS1PRSS2PRSS3 | |
| SCHEMBL28452781 | 0.80 | F11 (0.35) | F11F2PRSS1PRSS2PRSS3 | |
| SCHEMBL3823509 | 0.76 | CCNC (0.34) | F11F2PRSS1PRSS2PRSS3 | |
| SCHEMBL21358508 | 0.74 | F11 (0.44) | F11F2PRSS1PRSS2PRSS3 | |
| SCHEMBL5706992 | 0.74 | CDC7 (0.34) | F11F2PRSS1PRSS2PRSS3 | |
| SCHEMBL1163798 | 0.74 | F11 (0.44) | F11F2PRSS1PRSS2PRSS3 | |
| SCHEMBL428319 | 0.74 | F11 (0.44) | F11F2PRSS1PRSS2PRSS3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1709028-A1 | FUSED HETEROARYL DERIVATIVES AND THEIR USE AS P38 KINASE INHIBITORS | SMITHKLINE BEECHAM CORPORATION (US) | 2006-10-11 | — | — | EP | disclosed |
| EP-1708996-A1 | FUSED HETEROYRAL DERIVATIVES FOR USE AS P38 KINASE INHIBITORS | SMITHKLINE BEECHAM CORPORATION (US) | 2006-10-11 | — | — | EP | disclosed |
| WO-2005073189-A1 | FUSED HETEROYRAL DERIVATIVES FOR USE AS P38 KINASE INHIBITORS | SMITHKLINE BEECHAM CORPORATION (US) | 2005-08-11 | — | — | WO | disclosed |
| WO-2005073217-A1 | FUSED HETEROARYL DERIVATIVES AND THEIR USE AS P38 KINASE INHIBITORS | SMITHKLINE BEECHAM CORPORATION (US) | 2005-08-11 | — | — | WO | disclosed |