Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | F11 | P03951 | 2/20 | 0.31 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.31 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.30 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.30 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.30 |
| ▸ | PARP1 | P09874 | 1/20 | 0.30 |
| ▸ | F2 | P00734 | 1/20 | 0.30 |
| ▸ | PRSS1 | P07477 | 1/20 | 0.30 |
| ▸ | PRSS2 | P07478 | 1/20 | 0.30 |
| ▸ | PRSS3 | P35030 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5707007 | 0.83 | F11 (0.34) | F11F2PRSS1PRSS2PRSS3 | |
| SCHEMBL22468534 | 0.81 | LIPG (0.39) | F11F2PRSS1PRSS2PRSS3 | |
| SCHEMBL3823509 | 0.79 | CCNC (0.34) | F11ROCK2PARP1F2PRSS1 | |
| SCHEMBL1291127 | 0.77 | F11 (0.35) | F11ROCK2PARP1F2PRSS1 | |
| SCHEMBL6750664 | 0.77 | ROCK1 (0.39) | F11ROCK2F2PRSS1PRSS2 | |
| SCHEMBL5706992 | 0.77 | CDC7 (0.34) | F11ROCK2PARP1F2PRSS1 | |
| SCHEMBL28452781 | 0.74 | F11 (0.35) | F11ROCK2PARP1F2PRSS1 | |
| SCHEMBL24298216 | 0.70 | LPL (0.34) | — | |
| SCHEMBL29457877 | 0.70 | LPL (0.34) | — | |
| SCHEMBL428319 | 0.69 | F11 (0.44) | F11F2PRSS1PRSS2PRSS3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1474395-A1 | NICOTINAMIDE DERIVATES USEFUL AS P38 INHIBITORS | SMITHKLINE BEECHAM CORPORATION (US) | 2004-11-10 | — | — | EP | disclosed |
| WO-2003068747-A1 | NICOTINAMIDE DERIVATES USEFUL AS P38 INHIBITORS | SMITHKLINE BEECHAM CORPORATION (US) | 2003-08-21 | — | — | WO | disclosed |