Known targets — ChEMBL curated mechanism
ACHEBDKRB2CHRM1CHRM2CHRM3CHRNA1CHRNB1CHRNDCHRNECHRNGGUCY1A1GUCY1A2GUCY1B1GUCY1B2NAMPTPTAFRSLC10A2SLC6A2SLC6A3TACR1dacAdacBdacCftsImrcAmrcBmrdA
The experimentally established mechanism targets of Hydrochloric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GAA | P10253 | 2/20 | 0.44 |
| ▸ | RAD52 | P43351 | 1/20 | 0.44 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.31 |
| ▸ | GSK3B | P49841 | 1/20 | 0.30 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.30 |
| ▸ | MAPT | P10636 | 1/20 | 0.30 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.30 |
| ▸ | HTT | P42858 | 1/20 | 0.30 |
| ▸ | RECQL | P46063 | 1/20 | 0.30 |
| ▸ | PTK2B | Q14289 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5707907 | 0.99 | GAA (0.45) | GAARAD52KCNH2GSK3BKDM4E | |
| Hydrochloric Acid SCHEMBL5707969 | 0.88 | KDM4E (0.39) | GAARAD52KCNH2KDM4EMAPT | |
| SCHEMBL5707962 | 0.87 | MAPT (0.40) | GAARAD52KCNH2KDM4EMAPT | |
| Hydrochloric Acid SCHEMBL5707958 | 0.81 | GAA (0.52) | GAARAD52KCNH2KDM4EMAPT | |
| Hydrochloric Acid SCHEMBL5707922 | 0.77 | GAA (0.49) | GAARAD52KCNH2GSK3BKDM4E | |
| Hydrochloric Acid SCHEMBL5707956 | 0.77 | GAA (0.56) | GAARAD52KCNH2KDM4EMAPT | |
| SCHEMBL5707910 | 0.76 | GAA (0.50) | GAARAD52KCNH2GSK3BKDM4E | |
| SCHEMBL5707930 | 0.76 | GAA (0.58) | GAARAD52KCNH2KDM4EMAPT | |
| SCHEMBL5203962 | 0.74 | GAA (0.65) | GAARAD52KCNH2KDM4EMAPT | |
| Hydrochloric Acid SCHEMBL2126545 | 0.74 | GAA (0.36) | GAARAD52 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1462445-B1 | Paraphenyldiamine derivatives concisting of a cyclic diaza group substituted by a cationic radical and use of these derivatives for dyeing keratin fibres | OREAL (FR) | 2006-10-18 | — | — | EP | claimed |
| US-7090703-B2 | Para-phenylenediamine derivatives comprising a cyclic diaza group substituted with a cationic radical, and use of these derivatives for dyeing keratin fibers | L'OREAL (FR) | 2006-08-15 | — | — | US | claimed |
| US-20060123565-A9 | PARA-PHENYLENEDIAMINE DERIVATIVES COMPRISING A CYCLIC DIAZA GROUP SUBSTITUTED WITH A CATIONIC RADICAL, AND USE OF THESE DERIVATIVES FOR DYEING KERATIN FIBERS | SABELLE STEPHANE | 2006-06-15 | — | — | US | claimed |
| US-20050066451-A1 | Para-phenylenediamine derivatives comprising a cyclic diaza group substituted with a cationic radical, and use of these derivatives for dyeing keratin fibers | L'OREAL S.A. (FR) | 2005-03-31 | — | — | US | claimed |
| US-7090703-B2 | Para-phenylenediamine derivatives comprising a cyclic diaza group substituted with a cationic radical, and use of these derivatives for dyeing keratin fibers | L'OREAL (FR) | 2006-08-15 | — | — | US | disclosed |
| US-20060123565-A9 | PARA-PHENYLENEDIAMINE DERIVATIVES COMPRISING A CYCLIC DIAZA GROUP SUBSTITUTED WITH A CATIONIC RADICAL, AND USE OF THESE DERIVATIVES FOR DYEING KERATIN FIBERS | SABELLE STEPHANE | 2006-06-15 | — | — | US | disclosed |
| US-20050066451-A1 | Para-phenylenediamine derivatives comprising a cyclic diaza group substituted with a cationic radical, and use of these derivatives for dyeing keratin fibers | L'OREAL S.A. (FR) | 2005-03-31 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050066451-A1 | Para-phenylenediamine derivatives comprising a cyclic diaza group substituted with a cationic radical, and use of these derivatives for dyeing keratin fibers | KRT18, VIM, DDAH1 | GAA 4321/4885RAD52 1251/4885KCNH2 54/4885 |
| US-20060123565-A9 | PARA-PHENYLENEDIAMINE DERIVATIVES COMPRISING A CYCLIC DIAZA GROUP SUBSTITUTED WITH A CATIONIC RADICAL, AND USE OF THESE DERIVATIVES FOR DYEING KERATIN FIBERS | KRT18, VIM, DDAH1 | GAA 4321/4885RAD52 1251/4885KCNH2 54/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.