Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 7/20 | 0.54 |
| ▸ | NPC1 | O15118 | 5/20 | 0.54 |
| ▸ | TLR9 | Q9NR96 | 5/20 | 0.54 |
| ▸ | RAB9A | P51151 | 4/20 | 0.54 |
| ▸ | HTT | P42858 | 4/20 | 0.54 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.54 |
| ▸ | LMNA | P02545 | 2/20 | 0.54 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.54 |
| ▸ | TP53 | P04637 | 1/20 | 0.54 |
| ▸ | HPGD | P15428 | 1/20 | 0.54 |
| ▸ | XBP1 | P17861 | 1/20 | 0.54 |
| ▸ | MEN1 | O00255 | 12/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 12/20 | 0.50 |
| ▸ | POLB | P06746 | 3/20 | 0.50 |
| ▸ | MAPK1 | P28482 | 3/20 | 0.50 |
| ▸ | NPSR1 | Q6W5P4 | 3/20 | 0.50 |
| ▸ | OPRD1 | P41143 | 2/20 | 0.50 |
| ▸ | OPRK1 | P41145 | 2/20 | 0.50 |
| ▸ | GPR55 | Q9Y2T6 | 1/20 | 0.50 |
| ▸ | TNF | P01375 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3502541 | 0.84 | MEN1 (0.50) | MAPTNPC1TLR9RAB9AHTT | |
| SCHEMBL5708771 | 0.74 | NPC1 (0.73) | MAPTNPC1TLR9RAB9AHTT | |
| SCHEMBL5708812 | 0.74 | NQO2 (0.35) | ALDH1A1 | |
| SCHEMBL5708726 | 0.74 | KMT2A (0.47) | MAPTALDH1A1HPGDMEN1KMT2A | |
| SCHEMBL28373141 | 0.74 | MEN1 (0.46) | MAPTNPC1TLR9RAB9AHTT | |
| SCHEMBL18510270 | 0.71 | ALDH1A1 (0.41) | MAPTALDH1A1LMNA | |
| SCHEMBL3192786 | 0.70 | IDO1 (0.57) | MAPTHTTMEN1KMT2APOLB | |
| SCHEMBL5708833 | 0.70 | NPC1 (1.00) | MAPTNPC1TLR9RAB9AHTT | |
| SCHEMBL6759012 | 0.66 | ALDH1A1 (0.41) | ALDH1A1LMNA | |
| SCHEMBL4370342 | 0.64 | MEN1 (0.66) | MAPTALDH1A1LMNAMEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 19 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1328244-B1 | AGENT AND METHOD FOR COLOURING KERATIN FIBRES | WELLA AG (DE) | 2006-10-11 | — | — | EP | claimed |
| US-6773463-B2 | A MIXTURE OF A 4-NITRO-2,1,3-BENZOXADIAZOLE, A 4-NITRO-2,1,3-BENZOTHIADIAZOLE, OR A 4-NITRO-2,1,3-BENZO-SELENADIAZOLE AND AT LEAST ONE AMINE, PHENOL, OR AMINONITROBENZENE; INTENSE COLORATIONS; MILD CONDITIONS; DIRECT HAIR DYE | WELLA AKTIENGESELLSCHAFT (DE) | 2004-08-10 | — | — | US | claimed |
| EP-1328244-A1 | AGENT AND METHOD FOR COLOURING KERATIN FIBRES | Wella Aktiengesellschaft (DE) | 2003-07-23 | — | — | EP | claimed |
| US-20030070239-A1 | Agent and method for dyeing keratin fibers | HFC PRESTIGE INTERNATIONAL OPERATIONS SWITZERLAND SÀRL (CH) | 2003-04-17 | — | — | US | claimed |
| WO-2002022093-A1 | AGENT AND METHOD FOR COLOURING KERATIN FIBRES | WELLA AKTIENGESELLSCHAFT (DE) | 2002-03-21 | — | — | WO | claimed |
| CN-115485275-A | Compounds and compositions that inhibit HIF 2-alpha activity and methods of use thereof | 诺华股份有限公司 | 2022-12-16 | — | — | CN | disclosed |
| US-9757379-B2 | Inhibition of HIF-2α heterodimerization with HIF1β (ARNT) | THE BOARD OF REGENTS OF THE UNIVERSITY OF TEXAS SYSTEM (US) | 2017-09-12 | — | — | US | disclosed |
| US-9757379-B2 | Inhibition of HIF-2α heterodimerization with HIF1β (ARNT) | THE BOARD OF REGENTS OF THE UNIVERSITY OF TEXAS SYSTEM (US) | 2017-09-12 | — | — | US | disclosed |
| US-9757379-B2 | Inhibition of HIF-2α heterodimerization with HIF1β (ARNT) | THE BOARD OF REGENTS OF THE UNIVERSITY OF TEXAS SYSTEM (US) | 2017-09-12 | — | — | US | disclosed |
| US-20160250216-A1 | INHIBITION OF HIF-2ALPHA HETERODIMERIZATION WITH HIF1BETA (ARNT) | THE BOARD OF REGENTS OF THE UNIVERSITY OF TEXAS SYSTEM (US) | 2016-09-01 | — | — | US | disclosed |
| US-20160250216-A1 | INHIBITION OF HIF-2ALPHA HETERODIMERIZATION WITH HIF1BETA (ARNT) | THE BOARD OF REGENTS OF THE UNIVERSITY OF TEXAS SYSTEM (US) | 2016-09-01 | — | — | US | disclosed |
| US-20160250216-A1 | INHIBITION OF HIF-2ALPHA HETERODIMERIZATION WITH HIF1BETA (ARNT) | THE BOARD OF REGENTS OF THE UNIVERSITY OF TEXAS SYSTEM (US) | 2016-09-01 | — | — | US | disclosed |
| EP-2919770-A2 | INHIBITION OF HIF-2 HETERODIMERIZATION WITH HIF1 (ARNT) | The Board of Regents of The University of Texas System (US) | 2015-09-23 | — | — | EP | disclosed |
| WO-2014078479-A2 | INHIBITION OF HIF-2α HETERODIMERIZATION WITH HIF1β (ARNT) | THE BOARD OF REGENTS OF THE UNIVERSITY OF TEXAS SYSTEM (US) | 2014-05-22 | — | — | WO | disclosed |
| EP-1328244-B1 | AGENT AND METHOD FOR COLOURING KERATIN FIBRES | WELLA AG (DE) | 2006-10-11 | — | — | EP | disclosed |
| US-6773463-B2 | A MIXTURE OF A 4-NITRO-2,1,3-BENZOXADIAZOLE, A 4-NITRO-2,1,3-BENZOTHIADIAZOLE, OR A 4-NITRO-2,1,3-BENZO-SELENADIAZOLE AND AT LEAST ONE AMINE, PHENOL, OR AMINONITROBENZENE; INTENSE COLORATIONS; MILD CONDITIONS; DIRECT HAIR DYE | WELLA AKTIENGESELLSCHAFT (DE) | 2004-08-10 | — | — | US | disclosed |
| EP-1328244-A1 | AGENT AND METHOD FOR COLOURING KERATIN FIBRES | Wella Aktiengesellschaft (DE) | 2003-07-23 | — | — | EP | disclosed |
| US-20030070239-A1 | Agent and method for dyeing keratin fibers | HFC PRESTIGE INTERNATIONAL OPERATIONS SWITZERLAND SÀRL (CH) | 2003-04-17 | — | — | US | disclosed |
| WO-2002022093-A1 | AGENT AND METHOD FOR COLOURING KERATIN FIBRES | WELLA AKTIENGESELLSCHAFT (DE) | 2002-03-21 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20160250216-A1 | INHIBITION OF HIF-2ALPHA HETERODIMERIZATION WITH HIF1BETA (ARNT) | HIF1AN, HIF1A, EGLN2 | MAPT 4061/4885NPC1 2955/4885TLR9 4723/4885 |
| US-20030070239-A1 | Agent and method for dyeing keratin fibers | KRT18, AOC1, S100B | MAPT 2273/4885NPC1 4185/4885TLR9 4225/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.