SCHEMBL570957

SCHEMBL570957

CCc1c(C(N)=O)c(=O)oc2ccc(C=CC(=O)c3ccc(C)cc3)cc12

nearest known ligand 0.46

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
MAPT P10636 7/20 0.46
MAOB P27338 6/20 0.43
MAOA P21397 4/20 0.43
RAB9A P51151 2/20 0.43
POLB P06746 1/20 0.43
ACHE P22303 1/20 0.42
CXCL12 P48061 1/20 0.42
ALDH1A1 P00352 4/20 0.41
CYP1B1 Q16678 2/20 0.41
CYP3A4 P08684 1/20 0.41
HPGD P15428 1/20 0.41
MAPK1 P28482 1/20 0.41
RECQL P46063 1/20 0.41
TDP1 Q9NUW8 1/20 0.41
LMNA P02545 2/20 0.40
NPC1 O15118 1/20 0.40
CASP3 P42574 1/20 0.40
SENP8 Q96LD8 1/20 0.40
SENP7 Q9BQF6 1/20 0.40
SENP6 Q9GZR1 1/20 0.40

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL570976 0.80 MAOB (0.39) MAPTMAOBMAOARAB9APOLB
SCHEMBL25214446 0.75 RAB9A (0.44) MAPTMAOBRAB9AALDH1A1CYP3A4
SCHEMBL570891 0.72 MAOB (0.40) MAPTMAOBMAOARAB9APOLB
SCHEMBL570956 0.69 MAOB (0.49) MAPTMAOBMAOAACHEKDM4E
4,4'-Dimethylchalcone SCHEMBL979560 0.67 MAPT (1.00) MAPTMAOBMAOARAB9APOLB
4,4'-Dimethylchalcone SCHEMBL979559 0.67 MAPT (1.00) MAPTMAOBMAOARAB9APOLB
SCHEMBL9561400 0.67 MAPT (0.77) MAPTMAOBMAOARAB9APOLB
SCHEMBL9338261 0.67 MAPT (0.77) MAPTMAOBMAOARAB9APOLB
SCHEMBL28727204 0.67 MAPT (0.77) MAPTMAOBMAOARAB9APOLB
SCHEMBL13100090 0.66 NQO1 (0.81) MAPTMAOBRAB9AALDH1A1CYP3A4

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-2601183-A1 COUMARIN-CHALCONES AS ANTICANCER AGENTS Council Of Scientific & Industrial Research (IN) 2013-06-12 EP disclosed
WO-2012017454-A1 COUMARIN-CHALCONES AS ANTICANCER AGENTS COUNCIL OF SCIENTIFIC & INDUSTRIAL RESEARCH (IN) 2012-02-09 WO disclosed