Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CA1 | P00915 | 4/20 | 0.41 |
| ▸ | CA2 | P00918 | 4/20 | 0.41 |
| ▸ | TP53 | P04637 | 2/20 | 0.41 |
| ▸ | TSHR | P16473 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.39 |
| ▸ | LMNA | P02545 | 3/20 | 0.39 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.39 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
| ▸ | HPGD | P15428 | 1/20 | 0.39 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.39 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.39 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.39 |
| ▸ | CA12 | O43570 | 3/20 | 0.38 |
| ▸ | CA7 | P43166 | 3/20 | 0.38 |
| ▸ | CA9 | Q16790 | 3/20 | 0.38 |
| ▸ | CA14 | Q9ULX7 | 2/20 | 0.38 |
| ▸ | CA4 | P22748 | 1/20 | 0.38 |
| ▸ | ENPP2 | Q13822 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL248531 | 0.90 | — | — | |
| SCHEMBL10948473 | 0.74 | CA1 (0.45) | CA1CA2TP53TSHRALDH1A1 | |
| SCHEMBL6712521 | 0.70 | HDAC4 (0.42) | CA1CA2TP53TSHRALDH1A1 | |
| SCHEMBL1301200 | 0.69 | ALDH1A1 (0.44) | ALDH1A1MAPK1MAPTHPGDALOX15 | |
| SCHEMBL14695561 | 0.69 | LTA4H (0.43) | TSHRALDH1A1LMNAMAPK1HPGD | |
| SCHEMBL9673377 | 0.69 | IRAK4 (0.42) | CA1CA2ALDH1A1LMNAKDM4E | |
| SCHEMBL2885322 | 0.69 | CA1 (0.50) | CA1CA2TP53TSHRALDH1A1 | |
| SCHEMBL5668038 | 0.69 | CA4 (0.35) | CA1CA2ALDH1A1LMNAKDM4E | |
| SCHEMBL3503728 | 0.68 | CA12 (0.52) | CA1CA2TSHRALDH1A1LMNA | |
| SCHEMBL123985 | 0.67 | CA1 (0.48) | CA1CA2TP53TSHRALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2451786-B1 | IMPROVED PROCESS FOR THE PREPARATION OF AMBRISENTAN AND NOVEL INTERMEDIATES THEREOF | CADILA HEALTHCARE LTD (IN) | 2014-01-22 | — | — | EP | claimed |
| WO-2012017441-A1 | IMPROVED PROCESS TO PREPARE S-2-HYDROXY-3-METHOXY-3,3-DIPHENYL PROPIONIC ACID | NATCO PHARMA LIMITED (IN) | 2012-02-09 | — | — | WO | disclosed |
| EP-0892788-A1 | NOVEL CARBOXYLIC ACID DERIVATIVES, THEIR PRODUCTION AND USE | BASF AKTIENGESELLSCHAFT (DE) | 1999-01-27 | — | — | EP | disclosed |
| WO-1997038982-A1 | NOVEL CARBOXYLIC ACID DERIVATIVES, THEIR PRODUCTION AND USE | BASF AKTIENGESELLSCHAFT (DE) | 1997-10-23 | — | — | WO | disclosed |