Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Bicarbonate. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CA1 | P00915 | 1/20 | 1.00 |
| ▸ | CA2 | P00918 | 1/20 | 1.00 |
| ▸ | CA9 | Q16790 | 1/20 | 1.00 |
| ▸ | FFAR3 | O14843 | 2/20 | 0.50 |
| ▸ | ACHE | P22303 | 1/20 | 0.50 |
| ▸ | LCK | P06239 | 1/20 | 0.50 |
| ▸ | FYN | P06241 | 1/20 | 0.50 |
| ▸ | TSHR | P16473 | 4/20 | 0.40 |
| ▸ | LMNA | P02545 | 3/20 | 0.40 |
| ▸ | LDHA | P00338 | 2/20 | 0.40 |
| ▸ | EGLN1 | Q9GZT9 | 2/20 | 0.40 |
| ▸ | LDHB | P07195 | 1/20 | 0.40 |
| ▸ | SRR | Q9GZT4 | 1/20 | 0.40 |
| ▸ | TP53 | P04637 | 1/20 | 0.40 |
| ▸ | ALKBH5 | Q6P6C2 | 1/20 | 0.40 |
| ▸ | SUCNR1 | Q9BXA5 | 1/20 | 0.40 |
| ▸ | EGLN3 | Q9H6Z9 | 1/20 | 0.40 |
| ▸ | OR51E2 | Q9H255 | 2/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Bicarbonate SCHEMBL11066368 | 1.00 | CA1 (1.00) | CA1CA2CA9FFAR3ACHE | |
| Bicarbonate SCHEMBL1250901 | 1.00 | CA1 (1.00) | CA1CA2CA9FFAR3ACHE | |
| Bicarbonate SCHEMBL6478072 | 1.00 | CA1 (1.00) | CA1CA2CA9FFAR3ACHE | |
| Bicarbonate SCHEMBL9672524 | 1.00 | CA1 (1.00) | CA1CA2CA9FFAR3ACHE | |
| Bicarbonate SCHEMBL7794 | 1.00 | — | — | |
| Bicarbonate SCHEMBL8322803 | 1.00 | CA1 (1.00) | CA1CA2CA9FFAR3ACHE | |
| Bicarbonate SCHEMBL570721 | 1.00 | CA1 (1.00) | CA1CA2CA9FFAR3ACHE | |
| Bicarbonate SCHEMBL15271537 | 1.00 | — | — | |
| Bicarbonate SCHEMBL1179 | 1.00 | — | — | |
| Bicarbonate SCHEMBL29131670 | 1.00 | CA1 (1.00) | CA1CA2CA9FFAR3ACHE |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 18 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-116987092-A | Isosorbide-derived polycarbonate monomer compound, and preparation method and application thereof | 同济大学 | 2023-11-03 | — | — | CN | claimed |
| CN-113122521-B | Polypeptides having lipase activity and uses thereof | 丰益国际有限公司 | 2024-05-14 | — | — | CN | disclosed |
| CN-116987092-A | Isosorbide-derived polycarbonate monomer compound, and preparation method and application thereof | 同济大学 | 2023-11-03 | — | — | CN | disclosed |
| US-20230165867-A1 | IMIDAZOLIDINONE DERIVATIVES AND MEDICAL USE THEREOF | KANGBAIDA (SICHUAN) BIOTECHNOLOGY CO., LTD. (CN) | 2023-06-01 | — | — | US | disclosed |
| CN-115867272-A | Administration of an enterically selective JAK3 inhibitor | 施万生物制药研发IP有限责任公司 | 2023-03-28 | — | — | CN | disclosed |
| EP-4137491-A1 | IMIDAZOLINONE DERIVATIVE AND USE THEREOF IN MEDICINE | Chengdu Baiyu Pharmaceutical Co., Ltd. (CN) | 2023-02-22 | — | — | EP | disclosed |
| CN-114315834-A | Imidazolidinone derivatives and their use in medicaments | 成都百裕制药股份有限公司 | 2022-04-12 | — | — | CN | disclosed |
| WO-2021215274-A1 | SKIN EXTERNAL AGENT COMPOSITION AND DEODORANT | 株式会社 資生堂 (JP) | 2021-10-28 | — | — | WO | disclosed |
| CN-112812460-A | Environment-friendly high-flame-retardance sheath material for PVC optical cable | 苏州汇博塑化有限公司 | 2021-05-18 | — | — | CN | disclosed |
| CN-110066689-B | Scale inhibitor for preventing coking of high-pressure hydrogenation heat exchanger of coking gasoline and diesel oil | 中海油天津化工研究设计院有限公司 | 2021-02-23 | — | — | CN | disclosed |
| CN-110801431-B | Construction and application of core-shell type intelligent nano delivery system | 山东大学 | 2020-11-17 | — | — | CN | disclosed |
| CN-110801431-A | Construction and application of core-shell type intelligent nano delivery system | 山东大学 | 2020-02-18 | — | — | CN | disclosed |
| US-8637492-B2 | Molecular transporter compositions comprising dendrimeric oligoguanidine with a tri-functional core that facilitates delivery into cells in vivo | GENE TOOLS, LLC (US) | 2014-01-28 | — | — | US | disclosed |
| US-20120035358-A1 | Molecular transporter compositions comprising dendrimeric oligoguanidine with a tri-functional core that facilitates delivery into cells in vivo | GENE TOOLS, LLC | 2012-02-09 | — | — | US | disclosed |
| US-7935816-B2 | Molecular transporter compositions comprising dendrimeric oligoguanidine with a triazine core that facilitate delivery into cells in vivo | GENE TOOLS, LLC (US) | 2011-05-03 | — | — | US | disclosed |
| US-20090171075-A1 | Molecular transporter compositions comprising dendrimeric oligoguanidine with a triazine core that facilitate delivery into cells in vivo | GENE TOOLS, LLC | 2009-07-02 | — | — | US | disclosed |
| US-20090111775-A1 | Molecular transporter compositions comprising dendrimeric oligoguanidine with a tri-functional core that facilitates delivery into cells in vivo | GENE TOOLS, LLC | 2009-04-30 | — | — | US | disclosed |
| WO-2009055027-A2 | MOLECULAR TRANSPORTER COMPOSITIONS COMPRISING DENDRIMERIC OLIGOGUANIDINE WITH A TRI-FUNCTIONAL CORE THAT FACILITATE DELIVERY INTO CELLS IN VIVO | LI YONG-FU (US) | 2009-04-30 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090111775-A1 | Molecular transporter compositions comprising dendrimeric oligoguanidine with a tri-functional core that facilitates delivery into cells in vivo | SLC29A2, SLC29A1, SLC2A9 | CA1 3443/4885CA2 1207/4885CA9 1290/4885 |
| US-20090171075-A1 | Molecular transporter compositions comprising dendrimeric oligoguanidine with a triazine core that facilitate delivery into cells in vivo | SLC18A1, SLC75A1, SLC2A1 | CA1 3467/4885CA2 1489/4885CA9 2337/4885 |
| US-20230165867-A1 | IMIDAZOLIDINONE DERIVATIVES AND MEDICAL USE THEREOF | SYMPK, PAICS, CYP2C9 | CA1 2510/4885CA2 1922/4885CA9 330/4885 |
| US-20120035358-A1 | Molecular transporter compositions comprising dendrimeric oligoguanidine with a tri-functional core that facilitates delivery into cells in vivo | SLC29A2, SLC29A1, SLC2A9 | CA1 3443/4885CA2 1207/4885CA9 1290/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.