SCHEMBL5710108

SCHEMBL5710108

CCCCS(=O)(=O)Nc1nccs1

nearest known ligand 0.52

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ALDH1A1 P00352 5/20 0.50
PKM P14618 3/20 0.50
L3MBTL1 Q9Y468 1/20 0.49
KDM4E B2RXH2 4/20 0.48
HPGD P15428 3/20 0.48
GAA P10253 1/20 0.48
MAPT P10636 1/20 0.48
LMNA P02545 3/20 0.46
SMN1; SMN2 Q16637 2/20 0.45
TDP1 Q9NUW8 2/20 0.45
CYP2C9 P11712 1/20 0.45
EDNRA P25101 1/20 0.45
SLC6A4 P31645 1/20 0.45
ADRA1A P35348 1/20 0.45
PRMT6 Q96LA8 1/20 0.45
MEN1 O00255 3/20 0.43
KMT2A Q03164 3/20 0.43
USP2 O75604 1/20 0.43
NPSR1 Q6W5P4 1/20 0.43
ACP1 P24666 1/20 0.43

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL11979598 0.90 ALDH1A1 (0.50) ALDH1A1PKMKDM4EGAAMAPT
SCHEMBL11979597 0.82 ACP1 (0.53) ALDH1A1PKMKDM4EGAAMAPT
SCHEMBL30419982 0.79 PKM (0.49) ALDH1A1PKML3MBTL1KDM4ELMNA
SCHEMBL8796963 0.77 ALDH1A1 (0.49) ALDH1A1PKMKDM4EMAPTLMNA
SCHEMBL13595015 0.75 ALDH1A1 (0.51) ALDH1A1PKMKDM4EMAPTLMNA
SCHEMBL2912774 0.74 ALDH1A1 (0.53) ALDH1A1PKMKDM4EMAPTLMNA
SCHEMBL28222616 0.72 L3MBTL1 (0.38) ALDH1A1PKML3MBTL1KDM4EHPGD
SCHEMBL30338934 0.72 EPHX2 (0.46) ALDH1A1PKMKDM4EMAPTLMNA
SCHEMBL648497 0.72 NPC1 (0.50) ALDH1A1PKML3MBTL1MAPTSMN1; SMN2
SCHEMBL8088783 0.72 ALDH1A1 (0.50) ALDH1A1PKMKDM4EMAPTLMNA

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-100455565-C Sulfonamide anions as catalysts for nco oligomerization BAYER MATERIALSCIENCE AG (DE) 2009-01-28 CN disclosed
EP-1654324-B1 SULPHONAMIDE ANIONS AS CATALYSTS FOR NCO OLIGOMERISATION BAYER MATERIALSCIENCE AG (DE) 2006-12-27 EP disclosed
CN-1833003-A Sulfonamide anions as catalysts for nco oligomerization BAYER MATERIALSCIENCE AG (DE) 2006-09-13 CN disclosed
US-7060817-B2 Sulfonamide anions as catalysts for NCO oligomerization BAYER MATERIALSCIENCE AG (DE) 2006-06-13 US disclosed
US-20050033005-A1 Sulfonamide anions as catalysts for NCO oligomerization BAYER MATERIALSCIENCE AG (DE) 2005-02-10 US disclosed