Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.49 |
| ▸ | LMNA | P02545 | 3/20 | 0.49 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.49 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.49 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.49 |
| ▸ | EDNRA | P25101 | 1/20 | 0.49 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.49 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.49 |
| ▸ | PRMT6 | Q96LA8 | 1/20 | 0.49 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.49 |
| ▸ | PKM | P14618 | 5/20 | 0.47 |
| ▸ | ACP1 | P24666 | 2/20 | 0.46 |
| ▸ | SCN3A | Q9NY46 | 2/20 | 0.46 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.44 |
| ▸ | USP2 | O75604 | 1/20 | 0.44 |
| ▸ | MAPT | P10636 | 1/20 | 0.44 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.44 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.42 |
| ▸ | MEN1 | O00255 | 2/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11979598 | 0.83 | ALDH1A1 (0.50) | ALDH1A1LMNASMN1; SMN2KDM4ECYP2C9 | |
| SCHEMBL5710108 | 0.77 | ALDH1A1 (0.50) | ALDH1A1LMNASMN1; SMN2KDM4ECYP2C9 | |
| SCHEMBL30419982 | 0.76 | PKM (0.49) | ALDH1A1LMNASMN1; SMN2KDM4ECYP2C9 | |
| SCHEMBL11979597 | 0.76 | ACP1 (0.53) | ALDH1A1LMNASMN1; SMN2KDM4ECYP2C9 | |
| SCHEMBL30338934 | 0.76 | EPHX2 (0.46) | ALDH1A1LMNASMN1; SMN2KDM4ECYP2C9 | |
| SCHEMBL10419649 | 0.75 | NAMPT (0.53) | ALDH1A1LMNASMN1; SMN2KDM4ECYP2C9 | |
| SCHEMBL28780801 | 0.75 | LMNA (0.57) | ALDH1A1LMNASMN1; SMN2KDM4ECYP2C9 | |
| SCHEMBL14009908 | 0.75 | ACP1 (0.61) | ALDH1A1LMNASMN1; SMN2KDM4ECYP2C9 | |
| SCHEMBL2912774 | 0.75 | ALDH1A1 (0.53) | ALDH1A1LMNASMN1; SMN2KDM4ECYP2C9 | |
| SCHEMBL1647188 | 0.75 | ALDH1A1 (0.57) | ALDH1A1LMNASMN1; SMN2KDM4ECYP2C9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0772606-A1 | SUBSTITUTED THIAZOLES FOR THE TREATMENT OF INFLAMMATION | G.D. SEARLE & CO. (US) | 1997-05-14 | — | — | EP | disclosed |
| WO-1996003392-A1 | SUBSTITUTED THIAZOLES FOR THE TREATMENT OF INFLAMMATION | G.D. SEARLE & CO. (US) | 1996-02-08 | — | — | WO | disclosed |