Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FOLH1 | Q04609 | 2/20 | 0.60 |
| ▸ | TGM2 | P21980 | 4/20 | 0.59 |
| ▸ | SIRT2 | Q8IXJ6 | 1/20 | 0.59 |
| ▸ | SIRT1 | Q96EB6 | 1/20 | 0.59 |
| ▸ | CASP1 | P29466 | 4/20 | 0.58 |
| ▸ | ITGB3 | P05106 | 3/20 | 0.58 |
| ▸ | ITGAV | P06756 | 3/20 | 0.58 |
| ▸ | CTSL | P07711 | 3/20 | 0.55 |
| ▸ | CTSS | P25774 | 1/20 | 0.55 |
| ▸ | ECE1 | P42892 | 1/20 | 0.53 |
| ▸ | PPARG | P37231 | 1/20 | 0.52 |
| ▸ | PPARA | Q07869 | 1/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5711236 | 1.00 | FOLH1 (0.60) | FOLH1TGM2SIRT2SIRT1CASP1 | |
| SCHEMBL8387978 | 0.94 | FOLH1 (0.65) | FOLH1TGM2SIRT2SIRT1ITGB3 | |
| SCHEMBL10421088 | 0.91 | FOLH1 (0.62) | FOLH1TGM2SIRT2SIRT1ITGB3 | |
| SCHEMBL1701581 | 0.90 | CTSL (0.65) | CASP1CTSLCTSSPPARGPPARA | |
| SCHEMBL1796250 | 0.90 | CTSL (0.65) | CASP1CTSLCTSSPPARGPPARA | |
| SCHEMBL2487005 | 0.90 | CTSL (0.65) | CASP1CTSLCTSSPPARGPPARA | |
| SCHEMBL7279464 | 0.89 | CTSK (0.55) | FOLH1TGM2SIRT2SIRT1ITGB3 | |
| SCHEMBL26641195 | 0.89 | FOLH1 (0.60) | FOLH1TGM2SIRT2SIRT1ITGB3 | |
| SCHEMBL600823 | 0.89 | FOLH1 (0.60) | FOLH1TGM2SIRT2SIRT1ITGB3 | |
| SCHEMBL19658555 | 0.89 | FOLH1 (0.60) | FOLH1TGM2SIRT2SIRT1ITGB3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1103560-B1 | NOVEL THIAZOLIDINE DERIVATIVES | SANTEN PHARMACEUTICAL CO LTD (JP) | 2006-12-27 | — | — | EP | disclosed |
| US-6410576-B1 | ANTIINFLAMMATORY AGENTS; CARDIOVASCULAR DISORDERS | SANTEN PHARMACEUTICAL CO., LTD. (JP) | 2002-06-25 | — | — | US | disclosed |
| EP-1103560-A1 | NOVEL THIAZOLIDINE DERIVATIVES | SANTEN PHARMACEUTICAL CO., LTD. (JP) | 2001-05-30 | — | — | EP | disclosed |