Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAOA | P21397 | 1/20 | 0.46 |
| ▸ | MAOB | P27338 | 1/20 | 0.46 |
| ▸ | MTNR1A | P48039 | 4/20 | 0.41 |
| ▸ | MTNR1B | P49286 | 4/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.38 |
| ▸ | PLA2G10 | O15496 | 1/20 | 0.36 |
| ▸ | BCL2L1 | Q07817 | 1/20 | 0.35 |
| ▸ | SLC6A4 | P31645 | 2/20 | 0.35 |
| ▸ | CA1 | P00915 | 1/20 | 0.34 |
| ▸ | CA2 | P00918 | 1/20 | 0.34 |
| ▸ | CA4 | P22748 | 1/20 | 0.34 |
| ▸ | CA7 | P43166 | 1/20 | 0.34 |
| ▸ | CA9 | Q16790 | 1/20 | 0.34 |
| ▸ | NR3C1 | P04150 | 1/20 | 0.33 |
| ▸ | PGR | P06401 | 1/20 | 0.33 |
| ▸ | NR3C2 | P08235 | 1/20 | 0.33 |
| ▸ | LMNA | P02545 | 1/20 | 0.33 |
| ▸ | POLB | P06746 | 1/20 | 0.33 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12610426 | 0.71 | MAOA (0.57) | MAOAMAOBMTNR1AMTNR1BALDH1A1 | |
| SCHEMBL19014774 | 0.70 | MAOA (0.47) | MAOAMAOBMTNR1AMTNR1BALDH1A1 | |
| SCHEMBL19014864 | 0.70 | MAOA (0.47) | MAOAMAOBMTNR1AMTNR1BALDH1A1 | |
| SCHEMBL13503887 | 0.70 | BCL2L1 (0.48) | MAOAMAOBMTNR1AMTNR1BALDH1A1 | |
| SCHEMBL24088816 | 0.70 | MAOA (0.61) | MAOAMAOBMTNR1AMTNR1BALDH1A1 | |
| SCHEMBL5314709 | 0.70 | MAOA (0.61) | MAOAMAOBMTNR1AMTNR1BALDH1A1 | |
| SCHEMBL13074353 | 0.70 | MAOA (0.61) | MAOAMAOBMTNR1AMTNR1BALDH1A1 | |
| SCHEMBL6470751 | 0.69 | ALDH1A1 (0.40) | MAOAMAOBMTNR1AMTNR1BALDH1A1 | |
| SCHEMBL19014869 | 0.69 | MAOA (0.39) | MAOAMAOBMTNR1AMTNR1BALDH1A1 | |
| SCHEMBL14409753 | 0.69 | HTR2A (0.45) | MAOAMAOBMTNR1AMTNR1BPLA2G10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2601177-A1 | N-ACYLSULFONAMIDE APOPTOSIS PROMOTERS | AstraZeneca AB (SE) | 2013-06-12 | — | — | EP | disclosed |
| WO-2012017251-A1 | N-ACYLSULFONAMIDE APOPTOSIS PROMOTERS | ASTRAZENECA AB (SE) | 2012-02-09 | — | — | WO | disclosed |