Benzoic Acid

Benzoic Acid

SCHEMBL16044142

CC(C)C(O)CC(O)C(C)C.O=C(O)c1ccccc1.O=S(=O)(O)c1ccccc1

nearest known ligand 0.48

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Known targets — ChEMBL curated mechanism

BTKCACNA1CCACNA1DCACNA1FCACNA1SCACNA2D1CACNA2D2DRD2GABRA1GABRA2GABRA3GABRA4GABRA5GABRA6GABRB1GABRB2GABRB3GABRDGABREGABRG1GABRG2GABRG3GABRPGABRQHRH1HTR2AP2RY12

The experimentally established mechanism targets of Benzoic Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
TSHR P16473 3/20 0.48
SMN1; SMN2 Q16637 1/20 0.48
DAO P14920 1/20 0.42
NAPRT Q6XQN6 1/20 0.42
TAS2R14 Q9NYV8 3/20 0.40
HSD17B10 Q99714 1/20 0.40
LCK P06239 1/20 0.40
FYN P06241 1/20 0.40
MCL1 Q07820 1/20 0.39
CA2 P00918 2/20 0.38
CA12 O43570 1/20 0.38
CA9 Q16790 1/20 0.38
CES2 O00748 1/20 0.38
CES1 P23141 1/20 0.38
SRD5A2 P31213 1/20 0.38
LARS1 Q9P2J5 1/20 0.38
CA1 P00915 1/20 0.37
HSD11B1 P28845 2/20 0.37
MEN1 O00255 1/20 0.37
KMT2A Q03164 1/20 0.37

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL16045293 0.91 TSHR (0.59) TSHRSMN1; SMN2HSD17B10LARS1HSD11B1
Benzoic Acid SCHEMBL16044356 0.88 TSHR (0.52) TSHRSMN1; SMN2DAONAPRTTAS2R14
Benzoic Acid SCHEMBL571245 0.87 TSHR (0.56) TSHRSMN1; SMN2DAONAPRTCES2
Benzoic Acid SCHEMBL28686046 0.87 TSHR (0.56) TSHRSMN1; SMN2DAONAPRTCES2
Benzoic Acid SCHEMBL16046614 0.85 TSHR (0.57) TSHRSMN1; SMN2DAONAPRTTAS2R14
Benzoic Acid SCHEMBL16044736 0.84 TSHR (0.52) TSHRSMN1; SMN2DAONAPRTTAS2R14
Benzoic Acid SCHEMBL16046116 0.84 TSHR (0.52) TSHRSMN1; SMN2DAONAPRTTAS2R14
SCHEMBL28052980 0.84 ALDH1A1 (0.51) TSHRSMN1; SMN2KMT2ARAB9APOLB
Benzoic Acid SCHEMBL16048140 0.84 TSHR (0.47) TSHRSMN1; SMN2DAONAPRTTAS2R14
Benzoic Acid SCHEMBL16047778 0.84 TSHR (0.47) TSHRSMN1; SMN2DAONAPRTTAS2R14

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-109180843-B Non-phthalate compounds as electron donors for polyolefin catalysts 美国台塑公司 2022-03-01 CN claimed
EP-2969201-B1 NON-PHTHALATE COMPOUNDS AS ELECTRON DONORS FOR POLYOLEFIN CATALYSTS FORMOSA PLASTICS CORP USA (US) 2022-05-04 EP disclosed
CN-109180843-B Non-phthalate compounds as electron donors for polyolefin catalysts 美国台塑公司 2022-03-01 CN disclosed
US-9790291-B2 Non-phthalate compounds as electron donors for polyolefin catalysts FORMOSA PLASTICS CORPORATION, USA (US) 2017-10-17 US disclosed
EP-2969201-A2 NON-PHTHALATE COMPOUNDS AS ELECTRON DONORS FOR POLYOLEFIN CATALYSTS Formosa Plastics Corporation, U.S.A. (US) 2016-01-20 EP disclosed
WO-2014160012-A2 NON-PHTHALATE COMPOUNDS AS ELECTRON DONORS FOR POLYOLEFIN CATALYSTS FORMOSA PLASTICS CORPORATION, USA (US) 2014-10-02 WO disclosed
US-20140275456-A1 NON-PHTHALATE COMPOUNDS AS ELECTRON DONORS FOR POLYOLEFIN CATALYSTS FORMOSA PLASTICS CORPORATION, USA (US) 2014-09-18 US disclosed