SCHEMBL5712929

SCHEMBL5712929

OC(CBr)Cc1ccccc1

nearest known ligand 0.48

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
TRPA1 O75762 4/20 0.48
CYP1A2 P05177 1/20 0.46
EPHX1 P07099 1/20 0.46
ALDH1A1 P00352 1/20 0.46
TSHR P16473 1/20 0.46
CPA1 P15085 1/20 0.44
SRR Q9GZT4 2/20 0.44
ALPI P09923 1/20 0.43
PKM P14618 1/20 0.43
PTGS1 P23219 1/20 0.43
XIAP P98170 1/20 0.43
SLC7A5 Q01650 1/20 0.43
SLC6A2 P23975 2/20 0.43
TAAR1 Q96RJ0 2/20 0.43
MAOA P21397 1/20 0.43
SLC6A4 P31645 1/20 0.43
SLC6A3 Q01959 1/20 0.43
SIGMAR1 Q99720 1/20 0.43
CYP2A6 P11509 1/20 0.43
ADORA2A P29274 1/20 0.43

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL29033883 0.87 SRR (0.50) CYP1A2ALDH1A1TSHRSRRPTGS1
SCHEMBL29033881 0.87 SRR (0.50) CYP1A2ALDH1A1TSHRSRRPTGS1
SCHEMBL1833635 0.85 TRPA1 (0.55) TRPA1CYP1A2EPHX1TSHRSRR
Ammonia Solution, Strong SCHEMBL29021310 0.82 TRPA1 (0.53) TRPA1CYP1A2EPHX1TSHRSRR
SCHEMBL3091836 0.80 TRPA1 (0.52) TRPA1CYP1A2EPHX1SRRALPI
SCHEMBL5105980 0.80 TRPA1 (0.52) TRPA1CYP1A2EPHX1SRRALPI
SCHEMBL3091848 0.80 TRPA1 (0.52) TRPA1CYP1A2EPHX1SRRALPI
SCHEMBL22467712 0.79 TAAR1 (0.48) CYP1A2ALDH1A1SLC7A5SLC6A2TAAR1
SCHEMBL27548985 0.79 TRPA1 (0.43) TRPA1CYP1A2EPHX1ALDH1A1TSHR
SCHEMBL2211027 0.78 TRPA1 (0.56) TRPA1CYP1A2EPHX1TSHRSRR

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 15 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-6184323-B1 FOR OPHTHALMIC LENSES ESSILOR INTERNATIONAL-COMPAGNIE GENERALE D'OPTIQUE (FR) 2001-02-06 US claimed
EP-0745621-B1 Polymerisable composition based on thio(meth)acrylate monomer, transparent polymer compositions and their optical use ESSILOR INT (FR) 1998-04-15 EP claimed
US-3985808-A SECONDARY ALCOHOLS OR HALOHYDRINS REACTED WITH A HALOGEN LEVER BROTHERS COMPANY (US) 1976-10-12 US claimed
US-3944568-A Process for the preparation of selectively halogenated ketals LEVER BROTHERS COMPANY (US) 1976-03-16 US claimed
CN-117700374-A Preparation method of chiral high morpholine-3-formic acid 吉尔多肽生物制药(大连市)有限公司 2024-03-15 CN disclosed
EP-1723159-A2 MACROCYCLIC COMPOUNDS AND METHODS OF MAKING AND USING THE SAME Rib-X Pharmaceuticals, Inc. (US) 2006-11-22 EP disclosed
WO-2005085266-A2 MACROCYCLIC COMPOUNDS AND METHODS OF MAKING AND USING THE SAME RIB-X PHARMACEUTICALS, INC. (US) 2005-09-15 WO disclosed
US-20020049289-A1 Novel (thio) (meth) acrylate monomers, intermediate compounds for the synthesis of these monomers polymerizable compositions and polymers obtained, and their optical and ophthalmic uses ESSILOR COMPAGNIE GENERALE D'OPTIQUE 2002-04-25 US disclosed
US-6184323-B1 FOR OPHTHALMIC LENSES ESSILOR INTERNATIONAL-COMPAGNIE GENERALE D'OPTIQUE (FR) 2001-02-06 US disclosed
US-5633379-A N-METHYLASPARTIC ACID ANTAGONIST CIBA-GEIGY CORPORATION (US) 1997-05-27 US disclosed
CN-1120538-A 3-heteroaliphatyl- and 3-hetero (aryl) aliphatyl-2(1H)-quinolone dericatives CIBA GEIGY AG (CH) 1996-04-17 CN disclosed
EP-0685466-A1 3-Heteroaliphatyle-and 3-hetero-(aryle)-aliphatyle-2(1H)-quinolone derivatives CIBA-GEIGY AG (CH) 1995-12-06 EP disclosed
EP-0099148-A1 Piperazine derivatives, processes for their preparation and pharmaceutical preparations containing them GIST-BROCADES N.V. (NL) 1984-01-25 EP disclosed
US-3985808-A SECONDARY ALCOHOLS OR HALOHYDRINS REACTED WITH A HALOGEN LEVER BROTHERS COMPANY (US) 1976-10-12 US disclosed
US-3944568-A Process for the preparation of selectively halogenated ketals LEVER BROTHERS COMPANY (US) 1976-03-16 US disclosed