Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 3/20 | 1.00 |
| ▸ | SOAT1 | P35610 | 2/20 | 1.00 |
| ▸ | CNR1 | P21554 | 1/20 | 0.89 |
| ▸ | FAAH | O00519 | 3/20 | 0.89 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.89 |
| ▸ | MEN1 | O00255 | 1/20 | 0.89 |
| ▸ | TP53 | P04637 | 1/20 | 0.89 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.89 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.89 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.89 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.73 |
| ▸ | F7 | P08709 | 4/20 | 0.73 |
| ▸ | F3 | P13726 | 4/20 | 0.73 |
| ▸ | PPARG | P37231 | 3/20 | 0.73 |
| ▸ | PPARD | Q03181 | 3/20 | 0.73 |
| ▸ | PPARA | Q07869 | 3/20 | 0.73 |
| ▸ | FFAR1 | O14842 | 3/20 | 0.73 |
| ▸ | FABP3 | P05413 | 3/20 | 0.73 |
| ▸ | PTGS1 | P23219 | 2/20 | 0.73 |
| ▸ | DUSP3 | P51452 | 1/20 | 0.73 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL571437 | 1.00 | KDM4E (1.00) | KDM4ESOAT1CNR1FAAHCYP3A4 | |
| SCHEMBL10445407 | 1.00 | KDM4E (1.00) | KDM4ESOAT1CNR1FAAHCYP3A4 | |
| SCHEMBL10445589 | 1.00 | KDM4E (1.00) | KDM4ESOAT1CNR1FAAHCYP3A4 | |
| SCHEMBL124306 | 1.00 | KDM4E (1.00) | KDM4ESOAT1CNR1FAAHCYP3A4 | |
| SCHEMBL7626693 | 1.00 | KDM4E (1.00) | KDM4ESOAT1CNR1FAAHCYP3A4 | |
| SCHEMBL5905645 | 1.00 | KDM4E (1.00) | KDM4ESOAT1CNR1FAAHCYP3A4 | |
| SCHEMBL18619526 | 1.00 | KDM4E (1.00) | KDM4ESOAT1CNR1FAAHCYP3A4 | |
| SCHEMBL469581 | 1.00 | KDM4E (1.00) | KDM4ESOAT1CNR1FAAHCYP3A4 | |
| SCHEMBL10445415 | 1.00 | KDM4E (1.00) | KDM4ESOAT1CNR1FAAHCYP3A4 | |
| SCHEMBL10445406 | 1.00 | KDM4E (1.00) | KDM4ESOAT1CNR1FAAHCYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 92 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-12516321-B2 | RNA interference mediated inhibition of gene expression using short interfering nucleic acids (siNA) | SIRNA THERAPEUTICS, INC. (US) | 2026-01-06 | — | — | US | disclosed |
| US-20250066791-A1 | RNA INTERFERENCE MEDIATED INHIBITION OF PROLYL HYDROXYLASE DOMAIN 2 (PHD2) GENE EXPRESSION USING SHORT INTERFERING NUCLEIC ACID (SINA) | BANK OF AMERICA, N.A. | 2025-02-27 | — | — | US | disclosed |
| US-20240287515-A1 | RNA INTERFERENCE MEDIATED INHIBITION OF GENE EXPRESSION USING SHORT INTERFERING NUCLEIC ACIDS (SINA) | BANK OF AMERICA, N.A. | 2024-08-29 | — | — | US | disclosed |
| EP-3943114-B1 | NOVEL LOW MOLECULAR WEIGHT CATIONIC LIPIDS FOR OLIGONUCLEOTIDE DELIVERY | SIRNA THERAPEUTICS INC (US) | 2024-08-07 | — | — | EP | disclosed |
| US-11952573-B2 | RNA interference mediated inhibition of prolyl hydroxylase domain 2 (PHD2) gene expression using short interfering nucleic acid (siNA) | SIRNA THERAPEUTICS, INC. (US) | 2024-04-09 | — | — | US | disclosed |
| US-11932854-B2 | RNA interference mediated inhibition of gene expression using short interfering nucleic acids (siNA) | SIRNA THERAPEUTICS, INC. (US) | 2024-03-19 | — | — | US | disclosed |
| US-11911475-B2 | Low molecular weight cationic lipids for oligonucleotide delivery | SIRNA THERAPEUTICS, INC. (US) | 2024-02-27 | — | — | US | disclosed |
| US-20230030119-A1 | RNA INTERFERENCE MEDIATED INHIBITION OF CATENIN (CADHERIN-ASSOCIATED PROTEIN), BETA 1 (CTNNB1) GENE EXPRESSION USING SHORT INTERFERING NUCLEIC ACID (SINA) | SIRNA THERAPEUTICS, INC | 2023-02-02 | — | — | US | disclosed |
| US-20230000989-A1 | NOVEL LOW MOLECULAR WEIGHT CATIONIC LIPIDS FOR OLIGONUCLEOTIDE DELIVERY | SIRNA THERAPEUTICS, INC. (US) | 2023-01-05 | — | — | US | disclosed |
| US-20220380772-A1 | RNA INTERFERENCE MEDIATED INHIBITION OF PROLYL HYDROXYLASE DOMAIN 2 (PHD2) GENE EXPRESSION USING SHORT INTERFERING NUCLEIC ACID (SINA) | BANK OF AMERICA, N.A. | 2022-12-01 | — | — | US | disclosed |
| EP-2606134-A2 | RNA INTERFERENCE MEDIATED INHIBITION OF HEPATITIS B VIRUS (HBV) GENE EXPRESSION USING SHORT INTERFERING NUCLEIC ACID (siNA) | Merck Sharp & Dohme Corp. (US) | 2013-06-26 | — | — | EP | disclosed |
| US-20130150433-A1 | RNA Interference Mediated Inhibition of Hepatitis B Virus (HBV) Gene Expression Using Short Interfering Nucleic Acid (siNA) | BANK OF AMERICA, N.A. | 2013-06-13 | — | — | US | disclosed |
| EP-2601293-A2 | RNA INTERFERENCE MEDIATED INHIBITION OF CATENIN (CADHERIN-ASSOCIATED PROTEIN), BETA 1 (CTNNB1) GENE EXPRESSION USING SHORT INTERFERING NUCLEIC ACID (siNA) | Merck Sharp & Dohme Corp. (US) | 2013-06-12 | — | — | EP | disclosed |
| US-20130137752-A1 | RNA Interference Mediated Inhibition of Catenin (Cadherin-Associated Protein), Beta 1 (CTNNB1) Gene Expression Using Short Interfering Nucleic Acid (siNA) | BANK OF AMERICA, N.A. | 2013-05-30 | — | — | US | disclosed |
| WO-2012058210-A1 | RNA INTERFERENCE MEDIATED INHIBITION OF GENE EXPRESSION USING SHORT INTERFERING NUCLEIC ACIDS (siNA) | MERCK SHARP & DOHME CORP. (US) | 2012-05-03 | — | — | WO | disclosed |
| WO-2012054365-A2 | NOVEL LOW MOLECULAR WEIGHT CATIONIC LIPIDS FOR OLIGONUCLEOTIDE DELIVERY | MERCK SHARP & DOHME CORP. (US) | 2012-04-26 | — | — | WO | disclosed |
| WO-2012040184-A2 | NOVEL LOW MOLECULAR WEIGHT CATIONIC LIPIDS FOR OLIGONUCLEOTIDE DELIVERY | MERCK SHARP & DOHME CORP. (US) | 2012-03-29 | — | — | WO | disclosed |
| WO-2012027467-A1 | RNA INTERFERENCE MEDIATED INHIBITION OF PROLYL HYDROXYLASE DOMAIN 2 (PHD2) GENE EXPRESSION USING SHORT INTERFERING NUCLEIC ACID (siNA) | MERCK SHARP & DOHME CORP. (US) | 2012-03-01 | — | — | WO | disclosed |
| WO-2012024170-A2 | RNA INTERFERENCE MEDIATED INHIBITION OF HEPATITIS B VIRUS (HBV) GENE EXPRESSION USING SHORT INTERFERING NUCLEIC ACID (siNA) | MERCK SHARP & DOHME CORP. (US) | 2012-02-23 | — | — | WO | disclosed |
| WO-2012018754-A2 | RNA INTERFERENCE MEDIATED INHIBITION OF CATENIN (CADHERIN-ASSOCIATED PROTEIN), BETA 1 (CTNNB1) GENE EXPRESSION USING SHORT INTERFERING NUCLEIC ACID (siNA) | MERCK SHARP & DOHME CORP. (US) | 2012-02-09 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (7 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-11932854-B2 | RNA interference mediated inhibition of gene expression using short interfering nucleic acids (siNA) | SNRPE, AGO2, SIN3A | KDM4E 4420/4885SOAT1 1514/4885CNR1 4165/4885 |
| US-20220380772-A1 | RNA INTERFERENCE MEDIATED INHIBITION OF PROLYL HYDROXYLASE DOMAIN 2 (PHD2) GENE EXPRESSION USING SHORT INTERFERING NUCLEIC ACID (SINA) | EGLN2, EGLN3, EGLN1 | KDM4E 677/4885SOAT1 1885/4885CNR1 4299/4885 |
| US-20230000989-A1 | NOVEL LOW MOLECULAR WEIGHT CATIONIC LIPIDS FOR OLIGONUCLEOTIDE DELIVERY | LDLR, LIPC, CETP | KDM4E 3313/4885SOAT1 360/4885CNR1 1861/4885 |
| US-11952573-B2 | RNA interference mediated inhibition of prolyl hydroxylase domain 2 (PHD2) gene expression using short interfering nucleic acid (siNA) | EGLN2, EGLN3, EGLN1 | KDM4E 677/4885SOAT1 1885/4885CNR1 4299/4885 |
| US-11911475-B2 | Low molecular weight cationic lipids for oligonucleotide delivery | LDLR, APOB, CETP | KDM4E 4017/4885SOAT1 164/4885CNR1 2187/4885 |
| US-20250066791-A1 | RNA INTERFERENCE MEDIATED INHIBITION OF PROLYL HYDROXYLASE DOMAIN 2 (PHD2) GENE EXPRESSION USING SHORT INTERFERING NUCLEIC ACID (SINA) | EGLN2, EGLN3, EGLN1 | KDM4E 677/4885SOAT1 1885/4885CNR1 4299/4885 |
| US-20240287515-A1 | RNA INTERFERENCE MEDIATED INHIBITION OF GENE EXPRESSION USING SHORT INTERFERING NUCLEIC ACIDS (SINA) | SNRPE, AGO2, SIN3A | KDM4E 4420/4885SOAT1 1514/4885CNR1 4165/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.