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SCHEMBL5715145

SCHEMBL5715145

CC1(C)CC(=O)N(CCc2ccc(OC(=O)N3CCN(c4ccc(CC(=O)O)cn4)CC3)cc2)C(=O)C1

nearest known ligand 0.42

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
▸ PANK3 Q9H999 2/20 0.42
▸ ME2 P23368 7/20 0.42
▸ ME1 P48163 7/20 0.42
▸ ME3 Q16798 7/20 0.42
▸ AOC3 Q16853 1/20 0.40
▸ GPR119 Q8TDV5 1/20 0.39
▸ WNT3A P56704 1/20 0.38
▸ ALDH1A1 P00352 2/20 0.38
▸ SMN1; SMN2 Q16637 2/20 0.37
▸ HSD17B10 Q99714 2/20 0.37
▸ HPGD P15428 2/20 0.37
▸ CYP1A2 P05177 1/20 0.37
▸ CYP3A4 P08684 1/20 0.37
▸ CYP2C9 P11712 1/20 0.37
▸ TSHR P16473 1/20 0.37
▸ MAPK1 P28482 1/20 0.37
▸ CYP2C19 P33261 1/20 0.37
▸ HRH3 Q9Y5N1 1/20 0.36
▸ HTR1A P08908 1/20 0.36
▸ CACNA1H O95180 1/20 0.36

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL5714605 0.92 AOC3 (0.42) PANK3ME2ME1ME3AOC3
SCHEMBL5714442 0.90 PANK3 (0.42) PANK3ME2ME1ME3AOC3
SCHEMBL5714458 0.89 PANK3 (0.44) PANK3ME2ME1ME3AOC3
SCHEMBL5714416 0.89 ME2 (0.44) PANK3ME2ME1ME3GPR119
SCHEMBL5714493 0.89 PANK3 (0.45) PANK3ME2ME1ME3GPR119
SCHEMBL5714322 0.86 SMN1; SMN2 (0.55) SMN1; SMN2HSD17B10HPGDCYP1A2CYP2C9
SCHEMBL5714651 0.85 HSD17B10 (0.52) ALDH1A1SMN1; SMN2HSD17B10HPGDCYP1A2
SCHEMBL5715436 0.83 HRH3 (0.41) ME2ME1ME3AOC3ALDH1A1
SCHEMBL5715059 0.82 AOC3 (0.40) PANK3ME2ME1ME3AOC3
SCHEMBL5714563 0.82 ME2 (0.43) PANK3ME2ME1ME3AOC3

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20060160819-A1 Substitued piperazine carbamates NOVO NORDISK A/S (DK) 2006-07-20 — — US claimed
CN-1798735-A 1-aryl-4- (aryloxycarbonyl) -piperazine derivatives as inhibitors of hormone sensitive lipase NOVO NORDISK AS (DK) 2006-07-05 — — CN claimed
EP-1636189-A1 1-ARYL-4-(ARYLOXYCARBONYL)-PIPERAZINE DERIVATIVES FOR USE AS INHIBITORS OF HORMONE SENSITIVE LIPASE NOVO NORDISK A/S (DK) 2006-03-22 — — EP claimed
WO-2004111007-A1 1-ARYL-4-(ARYLOXYCARBONYL)-PIPERAZINE DERIVATIVES FOR USE AS INHIBITORS OF HORMONE SENSITIVE LIPASE NOVO NORDISK A/S (DK) 2004-12-23 — — WO claimed
CN-1798735-A 1-aryl-4- (aryloxycarbonyl) -piperazine derivatives as inhibitors of hormone sensitive lipase NOVO NORDISK AS (DK) 2006-07-05 — — CN disclosed
EP-1636189-A1 1-ARYL-4-(ARYLOXYCARBONYL)-PIPERAZINE DERIVATIVES FOR USE AS INHIBITORS OF HORMONE SENSITIVE LIPASE NOVO NORDISK A/S (DK) 2006-03-22 — — EP disclosed
WO-2004111007-A1 1-ARYL-4-(ARYLOXYCARBONYL)-PIPERAZINE DERIVATIVES FOR USE AS INHIBITORS OF HORMONE SENSITIVE LIPASE NOVO NORDISK A/S (DK) 2004-12-23 — — WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20060160819-A1 Substitued piperazine carbamates LIPE, PNLIP, LIPC PANK3 1247/4885ME2 854/4885ME1 2914/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.