Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTT | P42858 | 1/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.47 |
| ▸ | LMNA | P02545 | 1/20 | 0.47 |
| ▸ | MAPT | P10636 | 1/20 | 0.47 |
| ▸ | PTGDR2 | Q9Y5Y4 | 1/20 | 0.44 |
| ▸ | HDAC3 | O15379 | 2/20 | 0.44 |
| ▸ | HDAC4 | P56524 | 2/20 | 0.44 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.44 |
| ▸ | HDAC7 | Q8WUI4 | 2/20 | 0.44 |
| ▸ | HDAC2 | Q92769 | 2/20 | 0.44 |
| ▸ | HDAC10 | Q969S8 | 2/20 | 0.44 |
| ▸ | HDAC11 | Q96DB2 | 2/20 | 0.44 |
| ▸ | HDAC8 | Q9BY41 | 2/20 | 0.44 |
| ▸ | HDAC6 | Q9UBN7 | 2/20 | 0.44 |
| ▸ | HDAC9 | Q9UKV0 | 2/20 | 0.44 |
| ▸ | HDAC5 | Q9UQL6 | 2/20 | 0.44 |
| ▸ | RAB9A | P51151 | 5/20 | 0.43 |
| ▸ | NPC1 | O15118 | 4/20 | 0.43 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.43 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5716750 | 0.90 | MAPT (0.50) | HTTALDH1A1LMNAMAPTPTGDR2 | |
| SCHEMBL5716716 | 0.88 | HTT (0.49) | HTTALDH1A1LMNAMAPTHDAC3 | |
| SCHEMBL7066962 | 0.85 | HDAC3 (0.54) | HTTALDH1A1LMNAMAPTHDAC3 | |
| SCHEMBL5716793 | 0.84 | HDAC3 (0.55) | ALDH1A1LMNAMAPTPTGDR2HDAC3 | |
| SCHEMBL5716825 | 0.82 | TUBB4A (0.53) | ALDH1A1LMNAMAPTPTGDR2HDAC3 | |
| SCHEMBL5716752 | 0.81 | HDAC3 (0.49) | HTTALDH1A1LMNAMAPTHDAC3 | |
| SCHEMBL5716675 | 0.80 | HDAC3 (0.43) | HTTALDH1A1LMNAMAPTHDAC3 | |
| SCHEMBL14053495 | 0.80 | ALDH1A1 (0.55) | ALDH1A1LMNAMAPTPTGDR2HDAC3 | |
| SCHEMBL5716718 | 0.78 | HTT (0.48) | HTTALDH1A1LMNAMAPTHDAC3 | |
| SCHEMBL1772350 | 0.77 | LMNA (0.53) | HTTALDH1A1LMNAMAPTPTGDR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1276720-B1 | 2-ACYL INDOL DERIVATIVES AND THEIR USE AS ANTI-TUMOUR AGENTS | BAXTER HEALTHCARE SA (CH) | 2006-12-20 | — | — | EP | disclosed |
| EP-1442015-A1 | USE OF 2-ACYLINDOLES IN THE TREATMENT OF TUMORS | Baxter Healthcare SA (CH) | 2004-08-04 | — | — | EP | disclosed |
| US-20030158216-A1 | 2-acyl indole derivatives and their use as antitumor agents | BAXTER ONCOLOGY GMBH | 2003-08-21 | — | — | US | disclosed |
| WO-2003037861-A1 | USE OF 2-ACYLINDOLES IN THE TREATMENT OF TUMORS | BAXTER HEALTHCARE SA (CH) | 2003-05-08 | — | — | WO | disclosed |
| US-20020091124-A1 | 2-acyl indole derivatives and their use as antitumor agents | BECKERS THOMAS (DE) | 2002-07-11 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20030158216-A1 | 2-acyl indole derivatives and their use as antitumor agents | IDO1, IDO2, INMT | HTT 1342/4885ALDH1A1 789/4885LMNA 3780/4885 |
| US-20020091124-A1 | 2-acyl indole derivatives and their use as antitumor agents | IDO1, IDO2, INMT | HTT 1342/4885ALDH1A1 789/4885LMNA 3780/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.