Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 2/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.40 |
| ▸ | MEN1 | O00255 | 2/20 | 0.40 |
| ▸ | CXCR3 | P49682 | 2/20 | 0.40 |
| ▸ | RXRA | P19793 | 1/20 | 0.39 |
| ▸ | RXRB | P28702 | 1/20 | 0.39 |
| ▸ | RXRG | P48443 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.38 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.38 |
| ▸ | HPGD | P15428 | 1/20 | 0.38 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.38 |
| ▸ | TP53 | P04637 | 1/20 | 0.37 |
| ▸ | MAPT | P10636 | 1/20 | 0.37 |
| ▸ | NSD2 | O96028 | 1/20 | 0.36 |
| ▸ | ESR1 | P03372 | 1/20 | 0.36 |
| ▸ | POLB | P06746 | 1/20 | 0.36 |
| ▸ | APEX1 | P27695 | 1/20 | 0.36 |
| ▸ | RECQL | P46063 | 1/20 | 0.36 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.36 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5716934 | 0.88 | LMNA (0.47) | LMNAKMT2AMEN1ALDH1A1HSD17B10 | |
| SCHEMBL5716946 | 0.81 | MMP9 (0.46) | LMNAKMT2AMEN1ALDH1A1HSD17B10 | |
| SCHEMBL5716963 | 0.80 | LMNA (0.50) | LMNAKMT2AMEN1CXCR3ALDH1A1 | |
| SCHEMBL4903420 | 0.77 | LMNA (0.57) | LMNAKMT2ARXRARXRBRXRG | |
| SCHEMBL4897933 | 0.73 | TAS2R14 (0.46) | LMNAKMT2AMEN1CXCR3ALDH1A1 | |
| SCHEMBL5373270 | 0.71 | POLB (0.63) | KMT2AMEN1POLBTDP1 | |
| SCHEMBL5395468 | 0.69 | LMNA (0.45) | LMNAKMT2AMEN1ALDH1A1HSD17B10 | |
| SCHEMBL1601182 | 0.69 | LMNA (0.61) | LMNAALDH1A1HSD17B10HPGDALOX15 | |
| SCHEMBL4903412 | 0.69 | LMNA (0.52) | LMNAKMT2AMEN1ALDH1A1TP53 | |
| SCHEMBL5716889 | 0.69 | LMNA (0.47) | LMNAKMT2AMEN1ALDH1A1HSD17B10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1725524-A1 | SUBSTITUTED HETEROARYL- AND PHENYLSULFAMOYL COMPOUNDS | Pfizer Products Incorporated (US) | 2006-11-29 | — | — | EP | disclosed |
| WO-2005092845-A1 | SUBSTITUTED HETEROARYL- AND PHENYLSULFAMOYL COMPOUNDS | PFIZER PRODUCTS INC. (US) | 2005-10-06 | — | — | WO | disclosed |