Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FKBP1A | P62942 | 8/20 | 0.52 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.42 |
| ▸ | LMNA | P02545 | 1/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.41 |
| ▸ | MEN1 | O00255 | 2/20 | 0.41 |
| ▸ | TSHR | P16473 | 3/20 | 0.41 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.41 |
| ▸ | RECQL | P46063 | 1/20 | 0.41 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5961946 | 0.80 | EPHX2 (0.51) | EPHX2ALDH1A1LMNAKDM4E | |
| SCHEMBL9727246 | 0.77 | FKBP1A (0.46) | FKBP1AALDH1A1KMT2AKDM4EMEN1 | |
| SCHEMBL5717121 | 0.75 | ALDH1A1 (0.56) | FKBP1AALDH1A1KMT2AKDM4EMEN1 | |
| SCHEMBL5716995 | 0.74 | FKBP1A (0.60) | FKBP1AALDH1A1KMT2ALMNAKDM4E | |
| SCHEMBL5717026 | 0.74 | FKBP1A (0.50) | FKBP1AALDH1A1KMT2AKDM4EMEN1 | |
| SCHEMBL5717019 | 0.73 | HCRTR1 (0.60) | FKBP1AALDH1A1KMT2ALMNAKDM4E | |
| SCHEMBL15380421 | 0.72 | FKBP1A (0.51) | FKBP1AALDH1A1KMT2ALMNAKDM4E | |
| SCHEMBL5717045 | 0.72 | FKBP1A (0.64) | FKBP1AALDH1A1KMT2ALMNAKDM4E | |
| SCHEMBL5717039 | 0.72 | FKBP1A (0.58) | FKBP1AALDH1A1KMT2ALMNAKDM4E | |
| SCHEMBL9727257 | 0.72 | FKBP1A (0.43) | FKBP1AALDH1A1KMT2AKDM4EMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1664010-A1 | SULFONAMIDES ANTAGONISING N-TYPE CALCIUM CHANNELS | Vernalis (R&D) Limited (GB) | 2006-06-07 | — | — | EP | disclosed |
| WO-2005068448-A1 | SULFONAMIDES ANTAGONISING N-TYPE CALCIUM CHANNELS | IONIX PHARMACEUTICALS LIMITED (GB) | 2005-07-28 | — | — | WO | disclosed |