Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | THRA | P10827 | 9/20 | 0.36 |
| ▸ | THRB | P10828 | 9/20 | 0.36 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.34 |
| ▸ | GAA | P10253 | 2/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.34 |
| ▸ | MEN1 | O00255 | 2/20 | 0.34 |
| ▸ | RAB9A | P51151 | 2/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.34 |
| ▸ | NPC1 | O15118 | 1/20 | 0.34 |
| ▸ | ABL1 | P00519 | 1/20 | 0.34 |
| ▸ | LMNA | P02545 | 1/20 | 0.34 |
| ▸ | MAPT | P10636 | 1/20 | 0.34 |
| ▸ | HPGD | P15428 | 1/20 | 0.34 |
| ▸ | RIN1 | Q13671 | 1/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.34 |
| ▸ | CFD | P00746 | 1/20 | 0.34 |
| ▸ | F11 | P03951 | 1/20 | 0.34 |
| ▸ | TPSB2 | P20231 | 1/20 | 0.34 |
| ▸ | PLAU | P00749 | 2/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4924012 | 0.95 | HSD17B10 (0.38) | HSD17B10ALDH1A1GAAKDM4EMEN1 | |
| SCHEMBL5718180 | 0.93 | MEN1 (0.36) | THRATHRBHSD17B10ALDH1A1GAA | |
| SCHEMBL5717919 | 0.91 | THRA (0.37) | THRATHRBHSD17B10ALDH1A1GAA | |
| SCHEMBL4930990 | 0.91 | THRB (0.42) | THRATHRBCFDF11TPSB2 | |
| SCHEMBL5722483 | 0.90 | THRA (0.36) | THRATHRBALDH1A1GAAKDM4E | |
| SCHEMBL5717903 | 0.90 | THRA (0.37) | THRATHRBHSD17B10ALDH1A1GAA | |
| SCHEMBL5722490 | 0.90 | THRA (0.43) | THRATHRBALDH1A1GAAMEN1 | |
| SCHEMBL5717901 | 0.89 | GPR139 (0.36) | THRATHRBHSD17B10ALDH1A1GAA | |
| SCHEMBL5717999 | 0.87 | NPC1 (0.41) | THRATHRBALDH1A1MEN1RAB9A | |
| SCHEMBL5717818 | 0.87 | HSD17B10 (0.35) | THRBHSD17B10ALDH1A1GAAKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1732533-A1 | THYROID RECEPTOR AGONISTS | KARO BIO AB (SE) | 2006-12-20 | — | — | EP | disclosed |
| WO-2005092317-A1 | THYROID RECEPTOR AGONISTS | KARO BIO AB (SE) | 2005-10-06 | — | — | WO | disclosed |