Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | THRB | P10828 | 14/20 | 0.38 |
| ▸ | THRA | P10827 | 13/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.34 |
| ▸ | MEN1 | O00255 | 1/20 | 0.34 |
| ▸ | ABL1 | P00519 | 1/20 | 0.34 |
| ▸ | LMNA | P02545 | 1/20 | 0.34 |
| ▸ | GAA | P10253 | 1/20 | 0.34 |
| ▸ | MAPT | P10636 | 1/20 | 0.34 |
| ▸ | HPGD | P15428 | 1/20 | 0.34 |
| ▸ | RAB9A | P51151 | 1/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.34 |
| ▸ | RIN1 | Q13671 | 1/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.34 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.33 |
| ▸ | TOP2A | P11388 | 1/20 | 0.33 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.32 |
| ▸ | HTT | P42858 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4931300 | 0.94 | ALDH1A1 (0.37) | ALDH1A1MEN1ABL1LMNAGAA | |
| SCHEMBL5717861 | 0.94 | THRA (0.36) | THRBTHRAALDH1A1MEN1ABL1 | |
| SCHEMBL4930388 | 0.92 | THRB (0.43) | THRBTHRA | |
| SCHEMBL5722767 | 0.92 | THRA (0.47) | THRBTHRAALDH1A1MEN1ABL1 | |
| SCHEMBL5717755 | 0.92 | THRA (0.37) | THRBTHRAALDH1A1MEN1ABL1 | |
| SCHEMBL5722584 | 0.90 | THRA (0.36) | THRBTHRAALDH1A1MEN1ABL1 | |
| SCHEMBL5718235 | 0.89 | ALDH1A1 (0.34) | THRBTHRAALDH1A1MEN1ABL1 | |
| SCHEMBL5722833 | 0.89 | THRA (0.45) | THRBTHRAALDH1A1MEN1ABL1 | |
| SCHEMBL5717860 | 0.88 | KMT2A (0.33) | THRBTHRAALDH1A1MEN1ABL1 | |
| SCHEMBL4935198 | 0.88 | ALDH1A1 (0.38) | THRBALDH1A1MEN1ABL1LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1732533-A1 | THYROID RECEPTOR AGONISTS | KARO BIO AB (SE) | 2006-12-20 | — | — | EP | disclosed |
| WO-2005092317-A1 | THYROID RECEPTOR AGONISTS | KARO BIO AB (SE) | 2005-10-06 | — | — | WO | disclosed |