Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | THRA | P10827 | 8/20 | 0.45 |
| ▸ | THRB | P10828 | 8/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.36 |
| ▸ | HPGD | P15428 | 2/20 | 0.36 |
| ▸ | MEN1 | O00255 | 2/20 | 0.36 |
| ▸ | RAB9A | P51151 | 2/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.36 |
| ▸ | ABL1 | P00519 | 1/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | GAA | P10253 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
| ▸ | RIN1 | Q13671 | 1/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.36 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.36 |
| ▸ | HTT | P42858 | 1/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.34 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.34 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.34 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.34 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5116899 | 0.95 | ALDH1A1 (0.39) | THRATHRBALDH1A1HPGDMEN1 | |
| SCHEMBL5722481 | 0.92 | THRA (0.44) | THRATHRBALDH1A1HPGDMEN1 | |
| SCHEMBL5722584 | 0.91 | THRA (0.36) | THRATHRBALDH1A1HPGDMEN1 | |
| SCHEMBL5112221 | 0.91 | THRB (0.53) | THRATHRBALDH1A1MEN1KMT2A | |
| SCHEMBL5722767 | 0.90 | THRA (0.47) | THRATHRBALDH1A1HPGDMEN1 | |
| SCHEMBL5722840 | 0.90 | ALDH1A1 (0.38) | THRATHRBALDH1A1HPGDMEN1 | |
| SCHEMBL5717856 | 0.89 | THRB (0.38) | THRATHRBALDH1A1HPGDMEN1 | |
| SCHEMBL5722466 | 0.88 | THRA (0.45) | THRATHRBALDH1A1HPGDMEN1 | |
| SCHEMBL5718235 | 0.88 | ALDH1A1 (0.34) | THRATHRBALDH1A1HPGDMEN1 | |
| SCHEMBL5722505 | 0.88 | THRB (0.42) | THRATHRBALDH1A1SMN1; SMN2MAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1732532-A1 | NOVEL PHARMACEUTICAL COMPOSITIONS COMPRISING AGONISTS OF THE THYROID RECEPTOR | KARO BIO AB (SE) | 2006-12-20 | — | — | EP | disclosed |
| WO-2005092316-A1 | NOVEL PHARMACEUTICAL COMPOSITIONS COMPRISING AGONISTS OF THE THYROID RECEPTOR | KARO BIO AB (SE) | 2005-10-06 | — | — | WO | disclosed |