Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MRGPRX4 | Q96LA9 | 2/20 | 0.35 |
| ▸ | PTGDR2 | Q9Y5Y4 | 3/20 | 0.33 |
| ▸ | PTGDR | Q13258 | 2/20 | 0.33 |
| ▸ | THRB | P10828 | 3/20 | 0.32 |
| ▸ | THRA | P10827 | 2/20 | 0.32 |
| ▸ | CXCR3 | P49682 | 2/20 | 0.32 |
| ▸ | AKR1B1 | P15121 | 1/20 | 0.32 |
| ▸ | PDE4A | P27815 | 1/20 | 0.32 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.32 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.32 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.32 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.32 |
| ▸ | EGLN1 | Q9GZT9 | 4/20 | 0.32 |
| ▸ | ITGB3 | P05106 | 1/20 | 0.31 |
| ▸ | ITGA2B | P08514 | 1/20 | 0.31 |
| ▸ | TAOK1 | Q7L7X3 | 1/20 | 0.31 |
| ▸ | TAOK3 | Q9H2K8 | 1/20 | 0.31 |
| ▸ | USP5 | P45974 | 1/20 | 0.30 |
| ▸ | FLT1 | P17948 | 1/20 | 0.30 |
| ▸ | EGLN3 | Q9H6Z9 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4929677 | 0.96 | MRGPRX4 (0.38) | MRGPRX4CXCR3AKR1B1PDE4APDE4B | |
| SCHEMBL5717902 | 0.89 | MRGPRX4 (0.33) | MRGPRX4CXCR3HSD17B10TAOK1TAOK3 | |
| SCHEMBL5718186 | 0.89 | PTGDR (0.34) | PTGDR2PTGDRTHRBTHRAPDE4A | |
| SCHEMBL5718269 | 0.87 | THRA (0.40) | MRGPRX4THRBTHRAEGLN1 | |
| SCHEMBL5717820 | 0.87 | ALDH1A1 (0.34) | MRGPRX4PTGDR2PTGDRTHRBTHRA | |
| SCHEMBL5717962 | 0.87 | F2 (0.37) | PTGDR2PTGDRTHRBTHRAPDE4A | |
| SCHEMBL4934191 | 0.87 | EGLN1 (0.36) | MRGPRX4THRBTHRAPDE4APDE4B | |
| SCHEMBL5718126 | 0.86 | MRGPRX4 (0.37) | MRGPRX4THRBTHRAAKR1B1HSD17B10 | |
| SCHEMBL5718139 | 0.86 | MRGPRX4 (0.38) | MRGPRX4THRBTHRAAKR1B1HSD17B10 | |
| SCHEMBL5717926 | 0.85 | PTPN1 (0.39) | MRGPRX4TAOK1TAOK3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1732533-A1 | THYROID RECEPTOR AGONISTS | KARO BIO AB (SE) | 2006-12-20 | — | — | EP | disclosed |
| WO-2005092317-A1 | THYROID RECEPTOR AGONISTS | KARO BIO AB (SE) | 2005-10-06 | — | — | WO | disclosed |