SCHEMBL5718124

SCHEMBL5718124

CCCNc1cccc(COc2c(Cl)cc(C(=O)NCC(=O)O)cc2Cl)c1.CCCNc1cccc(COc2c(Cl)cc(CC(=O)O)cc2Cl)c1

nearest known ligand 0.44

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
THRB P10828 3/20 0.44
THRA P10827 2/20 0.44
RAB9A P51151 4/20 0.42
NPC1 O15118 3/20 0.42
MEN1 O00255 3/20 0.42
KMT2A Q03164 3/20 0.42
PDE5A O76074 1/20 0.41
MRGPRX4 Q96LA9 5/20 0.40
SMN1; SMN2 Q16637 3/20 0.40
MAPT P10636 2/20 0.38
HPGD P15428 2/20 0.38
NPSR1 Q6W5P4 1/20 0.38
ALDH1A1 P00352 1/20 0.38
ABL1 P00519 1/20 0.38
LMNA P02545 1/20 0.38
GAA P10253 1/20 0.38
RIN1 Q13671 1/20 0.38
KDM4E B2RXH2 1/20 0.38
PLAU P00749 1/20 0.38
SENP5 Q96HI0 1/20 0.38

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL4931357 0.95 THRA (0.48) THRBTHRARAB9ANPC1MEN1
SCHEMBL4933395 0.90 THRB (0.52) THRBTHRARAB9ANPC1MEN1
SCHEMBL5717763 0.89 HSD17B10 (0.37) THRBTHRARAB9ANPC1MEN1
SCHEMBL5717970 0.89 RAB9A (0.43) THRBTHRARAB9ANPC1MEN1
SCHEMBL5718130 0.88 MRGPRX4 (0.41) THRBTHRARAB9ANPC1MEN1
SCHEMBL5717953 0.88 HSD17B10 (0.36) THRBTHRARAB9ANPC1MEN1
SCHEMBL5718070 0.88 PPARA (0.38) THRBTHRARAB9ANPC1MEN1
SCHEMBL4347509 0.87 THRA (0.57) THRBTHRARAB9ANPC1MEN1
SCHEMBL5722815 0.87 SENP1 (0.48) THRBTHRARAB9ANPC1MEN1
SCHEMBL5717999 0.87 NPC1 (0.41) THRBTHRARAB9ANPC1MEN1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1732533-A1 THYROID RECEPTOR AGONISTS KARO BIO AB (SE) 2006-12-20 EP disclosed
WO-2005092317-A1 THYROID RECEPTOR AGONISTS KARO BIO AB (SE) 2005-10-06 WO disclosed