Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TRPA1 | O75762 | 2/20 | 0.50 |
| ▸ | ATM | Q13315 | 1/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.44 |
| ▸ | THRB | P10828 | 1/20 | 0.38 |
| ▸ | HSD17B10 | Q99714 | 4/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.38 |
| ▸ | HPGD | P15428 | 3/20 | 0.38 |
| ▸ | RECQL | P46063 | 2/20 | 0.37 |
| ▸ | POLB | P06746 | 1/20 | 0.37 |
| ▸ | MAPT | P10636 | 1/20 | 0.37 |
| ▸ | MPI | P34949 | 1/20 | 0.37 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.37 |
| ▸ | CA1 | P00915 | 3/20 | 0.36 |
| ▸ | CA2 | P00918 | 3/20 | 0.36 |
| ▸ | CA12 | O43570 | 2/20 | 0.36 |
| ▸ | CA7 | P43166 | 2/20 | 0.36 |
| ▸ | CA9 | Q16790 | 2/20 | 0.36 |
| ▸ | CA14 | Q9ULX7 | 2/20 | 0.36 |
| ▸ | LMNA | P02545 | 3/20 | 0.36 |
| ▸ | ADAMTS4 | O75173 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5780751 | 0.83 | CA2 (0.45) | TRPA1ATMALDH1A1THRBHSD17B10 | |
| SCHEMBL476988 | 0.83 | CYP1A2 (0.43) | TRPA1ATMALDH1A1HSD17B10KDM4E | |
| SCHEMBL11876975 | 0.77 | CYP1A2 (0.50) | TRPA1ATMALDH1A1HSD17B10KDM4E | |
| SCHEMBL1698298 | 0.74 | TSHR (0.39) | TRPA1ATMALDH1A1HSD17B10KDM4E | |
| SCHEMBL335267 | 0.74 | CA2 (0.38) | TRPA1ATMALDH1A1THRBHSD17B10 | |
| SCHEMBL910072 | 0.73 | ALDH1A1 (0.41) | ALDH1A1CA1CA2CA7CA9 | |
| SCHEMBL6149952 | 0.73 | CD44 (0.50) | ALDH1A1HSD17B10KDM4EHPGDCA1 | |
| SCHEMBL21201383 | 0.73 | ACHE (0.48) | ALDH1A1POLBCA1CA2CA7 | |
| SCHEMBL7156428 | 0.73 | CES2 (0.39) | ALDH1A1THRBHSD17B10KDM4EHPGD | |
| SCHEMBL11508761 | 0.72 | CYP3A4 (0.39) | TRPA1TSHRCYP3A4CYP1A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012018854-A2 | PACTAMYCIN ANALOGS AND METHODS OF USE | STATE OF OREGON BY AND THROUGH THE STATE BOARD OF HIGHER EDUC. ON BEHALF OF OREGON STATE UNIVERSTITY (US) | 2012-02-09 | — | — | WO | claimed |
| US-9399652-B2 | Synthetic route to pactamycin and pactamycin analogs | THE UNIVERSITY OF NORTH CAROLINA AT CHAPEL HILL (US) | 2016-07-26 | — | — | US | disclosed |
| US-20150329570-A1 | SYNTHETIC ROUTE TO PACTAMYCIN AND PACTAMYCIN ANALOGS | NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT | 2015-11-19 | — | — | US | disclosed |
| WO-2014116792-A1 | SYNTHETIC ROUTE TO PACTAMYCIN AND PACTAMYCIN ANALOGS | THE UNIVERSITY OF NORTH CAROLINA AT CHAPEL HILL (US) | 2014-07-31 | — | — | WO | disclosed |
| US-20130231377-A1 | PACTAMYCIN ANALOGS AND METHODS OF USE | OREGON STATE UNIVERSITY (US) | 2013-09-05 | — | — | US | disclosed |
| WO-2012018854-A2 | PACTAMYCIN ANALOGS AND METHODS OF USE | STATE OF OREGON BY AND THROUGH THE STATE BOARD OF HIGHER EDUC. ON BEHALF OF OREGON STATE UNIVERSTITY (US) | 2012-02-09 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20130231377-A1 | PACTAMYCIN ANALOGS AND METHODS OF USE | MRPL9, PTCD3, MRPL38 | TRPA1 4806/4885ATM 4621/4885ALDH1A1 4226/4885 |
| US-20150329570-A1 | SYNTHETIC ROUTE TO PACTAMYCIN AND PACTAMYCIN ANALOGS | PAICS, DPM1, MANBA | TRPA1 4844/4885ATM 2090/4885ALDH1A1 1424/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.