Known targets — ChEMBL curated mechanism
ACHEADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB1ADRB2ADRB3APH1AAPH1BCHRM2CHRM3EZH2GRIN2AHTR1AHTR1BHTR1DHTR1FHTR3ANCSTNP2RY12PSEN1PSEN2PSENENSIGMAR1SLC6A2SLC6A3SLC6A4
The experimentally established mechanism targets of Bromide. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADRA2A known ✓ | P08913 | 3/20 | 0.38 |
| ▸ | ADRA2B known ✓ | P18089 | 2/20 | 0.38 |
| ▸ | ADRA2C known ✓ | P18825 | 2/20 | 0.38 |
| ▸ | ADRA1A known ✓ | P35348 | 2/20 | 0.38 |
| ▸ | ADRB2 known ✓ | P07550 | 1/20 | 0.36 |
| ▸ | HTR1A known ✓ | P08908 | 1/20 | 0.36 |
| ▸ | HTR1B known ✓ | P28222 | 1/20 | 0.36 |
| ▸ | SIGMAR1 known ✓ | Q99720 | 1/20 | 0.36 |
| ▸ | APOBEC3A | P31941 | 1/20 | 0.50 |
| ▸ | APOBEC3G | Q9HC16 | 1/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.42 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.42 |
| ▸ | RAD52 | P43351 | 2/20 | 0.40 |
| ▸ | RECQL | P46063 | 1/20 | 0.40 |
| ▸ | DRD3 | P35462 | 6/20 | 0.38 |
| ▸ | DRD2 | P14416 | 5/20 | 0.38 |
| ▸ | MAPT | P10636 | 3/20 | 0.38 |
| ▸ | LMNA | P02545 | 2/20 | 0.38 |
| ▸ | HTR2A | P28223 | 2/20 | 0.38 |
| ▸ | HRH1 | P35367 | 2/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5720428 | 0.98 | APOBEC3A (0.52) | APOBEC3AAPOBEC3GALDH1A1MAPK1RAD52 | |
| SCHEMBL8132842 | 0.74 | APOBEC3A (0.52) | APOBEC3AAPOBEC3GALDH1A1MAPK1RAD52 | |
| SCHEMBL19153815 | 0.74 | DPP4 (0.32) | — | |
| SCHEMBL19131904 | 0.70 | GRM5 (0.33) | — | |
| SCHEMBL18237620 | 0.70 | GRM5 (0.33) | MAPK1RAD52RECQLGAARAB9A | |
| SCHEMBL558522 | 0.69 | APOBEC3A (0.95) | APOBEC3AAPOBEC3GALDH1A1MAPK1RAD52 | |
| SCHEMBL624175 | 0.69 | — | — | |
| Bromide SCHEMBL5720527 | 0.68 | TSHR (0.46) | ALDH1A1MAPTLMNAHSD17B10POLB | |
| SCHEMBL27034730 | 0.67 | APOBEC3A (0.43) | APOBEC3AAPOBEC3GALDH1A1MAPK1RAD52 | |
| Hydrochloric Acid SCHEMBL963094 | 0.67 | APOBEC3A (0.83) | APOBEC3AAPOBEC3GALDH1A1MAPK1RAD52 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1318986-B1 | PROCESS FOR PREPARATION OF 2-AMINO-6-(ALKYL) AMINO-4,5,6,7-TETRAHYDROBENZOTHIAZOLES | SYNTHON BV (NL) | 2006-05-31 | — | — | EP | disclosed |
| US-6770761-B2 | BROMINATION OF 1,4-CYCLOHEXANEDIONE BY BROMINE IN AN ALCOHOLIC SOLVENT; TREATMENT WITH THIOUREA OR N-ACYLTHIOUREA; ISOMERIZATION, CYCLIZATION; PRAMIPEXOLE SYNTHESIS | SYNTHON BV (NL) | 2004-08-03 | — | — | US | disclosed |
| US-6727367-B2 | QUATERNIZING PRAMIPEXOLE INTO OPTICAL ISOMERS VIA REACTING MONOBASIC ACID ADDITION SALT WITH OPTICALLY ACTIVE ACID FORMING DIASTEREOMERIC MIXED SALTS AND PRECIPITATING FROM SOLVENT TO FORM SEPARATED DIASTEREOMERS | SYNTHON BV (NL) | 2004-04-27 | — | — | US | disclosed |
| US-20040068119-A1 | Process for resolution of 2-amino-6-propylamino-4,5,6,7-tetrahydrobenzthiazole and compounds therefor | POSPISILIK KAREL (CZ) | 2004-04-08 | — | — | US | disclosed |
| US-20040029936-A1 | Process for preparation of 2-amino-6 (alkyl) amino-4,5,6,7-tetrahydrobenzothiazoles | SYNTHON IP INC. | 2004-02-12 | — | — | US | disclosed |
| US-20020103240-A1 | Process for resolution of 2-amino-6-propylamino-4,5,6,7-tetrahydrobenzthiazole and compounds therefor | SYNTHON IP INC. | 2002-08-01 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20040068119-A1 | Process for resolution of 2-amino-6-propylamino-4,5,6,7-tetrahydrobenzthiazole and compounds therefor | NOTUM, SLC5A6, WEE2 | ADRA2A 3023/4885ADRA2B 1884/4885ADRA2C 1733/4885 |
| US-20020103240-A1 | Process for resolution of 2-amino-6-propylamino-4,5,6,7-tetrahydrobenzthiazole and compounds therefor | NOTUM, SLC5A6, WEE2 | ADRA2A 3023/4885ADRA2B 1884/4885ADRA2C 1733/4885 |
| US-20040029936-A1 | Process for preparation of 2-amino-6 (alkyl) amino-4,5,6,7-tetrahydrobenzothiazoles | PAH, HTR6, HTR4 | ADRA2A 55/4885ADRA2B 40/4885ADRA2C 33/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.