SCHEMBL5721749

SCHEMBL5721749

CC(C)c1ccccc1-c1c(-c2ccccc2)ccc2c1C=C(c1ccccc1)[CH]2

nearest known ligand 0.39

Predicted protein targets (top 9)

geneUniProtsupporting neighboursconfidence
CA12 O43570 1/20 0.35
CA1 P00915 1/20 0.35
CA2 P00918 1/20 0.35
CA9 Q16790 1/20 0.35
TRPA1 O75762 1/20 0.32
ATR Q13535 1/20 0.32
PPARA Q07869 2/20 0.32
PPARG P37231 1/20 0.32
PTPN5 P54829 1/20 0.32

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL5721844 0.84 CA12 (0.31) CA12CA1CA2CA9
SCHEMBL5721793 0.84 USP1 (0.36) CA12CA1CA2CA9PPARA
SCHEMBL5609823 0.84 HDAC4 (0.32)
SCHEMBL5721475 0.83 CA12 (0.33) CA12CA1CA2CA9TRPA1
SCHEMBL5721193 0.81 NPC1 (0.37) CA12CA1CA2CA9
SCHEMBL5721463 0.80 METAP2 (0.37)
SCHEMBL5721244 0.78 DPP4 (0.33) TRPA1ATRPPARAPPARGPTPN5
SCHEMBL5721925 0.75 CDC25A (0.31)
SCHEMBL5721381 0.74 METAP2 (0.33)
SCHEMBL5610232 0.74 METAP2 (0.32)

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1640377-A1 Metallocenes and catalyst compositions derived therefrom Exxonmobil Chemical Patents Inc. (US) 2006-03-29 EP disclosed