Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 2/20 | 0.50 |
| ▸ | CYP19A1 | P11511 | 2/20 | 0.49 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.47 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.47 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.47 |
| ▸ | MEN1 | O00255 | 2/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.45 |
| ▸ | HTT | P42858 | 1/20 | 0.45 |
| ▸ | PKM | P14618 | 1/20 | 0.44 |
| ▸ | HPGD | P15428 | 1/20 | 0.44 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.44 |
| ▸ | TP53 | P04637 | 1/20 | 0.44 |
| ▸ | VCAM1 | P19320 | 1/20 | 0.43 |
| ▸ | TBXA2R | P21731 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5429675 | 0.80 | LMNA (0.57) | LMNACYP19A1CYP2C19HTTVCAM1 | |
| SCHEMBL4969877 | 0.79 | MEN1 (0.56) | LMNAMEN1KMT2AHTTPKM | |
| SCHEMBL4966705 | 0.73 | NR1H3 (0.50) | LMNAMEN1KMT2AHTTHPGD | |
| SCHEMBL7211477 | 0.72 | CYP2D6 (0.66) | CYP2D6CYP2C9CYP2C19PKMHPGD | |
| SCHEMBL25547148 | 0.71 | MEN1 (0.62) | LMNACYP2D6CYP2C9CYP2C19MEN1 | |
| Ammonia Solution, Strong SCHEMBL28203960 | 0.69 | PKM (0.68) | LMNACYP19A1MEN1KMT2APKM | |
| SCHEMBL26547989 | 0.69 | KDM4E (0.60) | LMNACYP19A1KMT2AHTTTP53 | |
| SCHEMBL2073109 | 0.69 | VCAM1 (0.59) | LMNAMEN1KMT2AHTTVCAM1 | |
| SCHEMBL25240875 | 0.68 | CYP2D6 (0.49) | CYP2D6CYP2C9CYP2C19PKMHPGD | |
| SCHEMBL25254752 | 0.68 | CYP2D6 (0.49) | CYP2D6CYP2C9CYP2C19PKMHPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1673369-A1 | BENZIMIDAZOLE DERIVATIVES, COMPOSITIONS CONTAINING THEM, PREPARATION THEREOF AND USES THEREOF | AstraZeneca AB (SE) | 2006-06-28 | — | — | EP | disclosed |
| WO-2005030761-A1 | BENZIMIDAZOLE DERIVATIVES, COMPOSITIONS CONTAINING THEM, PREPARATION THEREOF AND USES THEREOF | ASTRAZENECA AB (SE) | 2005-04-07 | — | — | WO | disclosed |